eprintid: 10188960
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/18/89/60
datestamp: 2024-03-13 11:44:10
lastmod: 2024-03-13 11:44:10
status_changed: 2024-03-13 11:44:10
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Hemming, Karla
creators_name: Copas, Andrew
creators_name: Forbes, Andrew
creators_name: Kasza, Jessica
title: What type of cluster randomized trial for which setting?
ispublished: pub
divisions: UCL
divisions: B02
divisions: D01
divisions: G16
note: © 2024 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY
license (http://creativecommons.org/licenses/by/4.0/)
abstract: The cluster randomized trial allows a randomized evaluation when it is either not possible to randomize the individual or randomizing individuals would put the trial at high risk of contamination across treatment arms. There are many variations of the cluster randomized design, including the parallel design with or without baseline measures, the cluster randomized cross-over design, the stepped-wedge cluster randomized design, and more recently-developed variants such as the batched stepped-wedge design and the staircase design. Once it has been clearly established that there is a need for cluster randomization, one ever important question is which form the cluster design should take. If a design in which time is split into multiple trial periods is to be adopted (e.g. as in a stepped-wedge), researchers must decide whether the same participants should be measured in multiple trial periods (cohort sampling); or if different participants should be measured in each period (continual recruitment or cross-sectional sampling). Here we outline the different possible options and weigh up the pros and cons of the different design choices, which revolve around statistical efficiency, study logistics and the assumptions required.
date: 2024-02
date_type: published
publisher: Elsevier BV
official_url: http://dx.doi.org/10.1016/j.jeph.2024.202195
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2257120
doi: 10.1016/j.jeph.2024.202195
lyricists_name: Copas, Andrew
lyricists_id: AJCOP98
actors_name: Copas, Andrew
actors_id: AJCOP98
actors_role: owner
full_text_status: public
publication: Journal of Epidemiology and Population Health
volume: 72
number: 1
article_number: 202195
issn: 2950-4333
citation:        Hemming, Karla;    Copas, Andrew;    Forbes, Andrew;    Kasza, Jessica;      (2024)    What type of cluster randomized trial for which setting?                   Journal of Epidemiology and Population Health , 72  (1)    , Article 202195.  10.1016/j.jeph.2024.202195 <https://doi.org/10.1016/j.jeph.2024.202195>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10188960/1/1-s2.0-S2950433324000065-main.pdf