eprintid: 10188960 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/18/89/60 datestamp: 2024-03-13 11:44:10 lastmod: 2024-03-13 11:44:10 status_changed: 2024-03-13 11:44:10 type: article metadata_visibility: show sword_depositor: 699 creators_name: Hemming, Karla creators_name: Copas, Andrew creators_name: Forbes, Andrew creators_name: Kasza, Jessica title: What type of cluster randomized trial for which setting? ispublished: pub divisions: UCL divisions: B02 divisions: D01 divisions: G16 note: © 2024 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) abstract: The cluster randomized trial allows a randomized evaluation when it is either not possible to randomize the individual or randomizing individuals would put the trial at high risk of contamination across treatment arms. There are many variations of the cluster randomized design, including the parallel design with or without baseline measures, the cluster randomized cross-over design, the stepped-wedge cluster randomized design, and more recently-developed variants such as the batched stepped-wedge design and the staircase design. Once it has been clearly established that there is a need for cluster randomization, one ever important question is which form the cluster design should take. If a design in which time is split into multiple trial periods is to be adopted (e.g. as in a stepped-wedge), researchers must decide whether the same participants should be measured in multiple trial periods (cohort sampling); or if different participants should be measured in each period (continual recruitment or cross-sectional sampling). Here we outline the different possible options and weigh up the pros and cons of the different design choices, which revolve around statistical efficiency, study logistics and the assumptions required. date: 2024-02 date_type: published publisher: Elsevier BV official_url: http://dx.doi.org/10.1016/j.jeph.2024.202195 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2257120 doi: 10.1016/j.jeph.2024.202195 lyricists_name: Copas, Andrew lyricists_id: AJCOP98 actors_name: Copas, Andrew actors_id: AJCOP98 actors_role: owner full_text_status: public publication: Journal of Epidemiology and Population Health volume: 72 number: 1 article_number: 202195 issn: 2950-4333 citation: Hemming, Karla; Copas, Andrew; Forbes, Andrew; Kasza, Jessica; (2024) What type of cluster randomized trial for which setting? Journal of Epidemiology and Population Health , 72 (1) , Article 202195. 10.1016/j.jeph.2024.202195 <https://doi.org/10.1016/j.jeph.2024.202195>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10188960/1/1-s2.0-S2950433324000065-main.pdf