eprintid: 10188426 rev_number: 9 eprint_status: archive userid: 699 dir: disk0/10/18/84/26 datestamp: 2024-03-05 09:40:24 lastmod: 2024-10-28 15:28:21 status_changed: 2024-03-05 09:40:24 type: article metadata_visibility: show sword_depositor: 699 creators_name: De Angelis, Sara creators_name: Di Laura, Anna creators_name: Ramesh, Angelika creators_name: Henckel, Johann creators_name: Hart, Alister title: The role of bone remodeling in measuring migration of custom implants for large acetabular defects ispublished: inpress subjects: RNOH divisions: UCL divisions: B04 divisions: C05 divisions: F45 keywords: Acetabular defect, biomechanical bone remodeling, custom implants, implant migration, Paprosky IIIB defect note: Copyright © 2024 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: In revision total hip arthroplasty, achieving robust fixation is difficult and implant movement may occur over time. Bone may also rearrange around the implant as a result of mechanical loading, making the measurement of migration challenging. The study aimed to quantify changes in bone shape and implant position 1 year following acetabular reconstruction using custom three-dimensional-printed cups. This observational retrospective cohort study involved 23 patients with Paprosky type IIIB defects. Postop computed tomography scans taken within 1 week of surgery and at 1-year postsurgery were co-registered and analyzed. Three co-registration strategies were implemented including bone-to-bone and implant-to-implant. (1) Co-registration of the ipsilateral innominate bone (diseased anatomy) was used to measure changes in implant position. (2) Co-registration of the implant was carried out to quantify changes in the ipsilateral innominate bone shape. (3) Co-registration of the contralateral innominate bone (nondiseased anatomy) was performed to measure changes in the ipsilateral innominate bone shape and implant position. The median centroid distances (interquartile range [IQR]) were 2.3 mm (IQR: 3.7–1.7 mm) for changes in implant position, 2.4 mm (IQR: 3.6–1.6 mm) for changes in ipsilateral innominate bone shape, and 3.7 mm (IQR: 4.6–3.5 mm) for changes in ipsilateral innominate bone shape and implant position. Following acetabular reconstruction, implant movements and periprosthetic bone remodeling are physiological and of a similar extent. Surgeons and engineers should consider this when performing implant monitoring in these patients. date: 2024-02-26 date_type: published publisher: Wiley official_url: http://dx.doi.org/10.1002/jor.25818 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2254057 doi: 10.1002/jor.25818 lyricists_name: De Angelis, Sara lyricists_id: SDEAN50 actors_name: De Angelis, Sara actors_id: SDEAN50 actors_role: owner full_text_status: public publication: Journal of Orthopaedic Research issn: 0736-0266 citation: De Angelis, Sara; Di Laura, Anna; Ramesh, Angelika; Henckel, Johann; Hart, Alister; (2024) The role of bone remodeling in measuring migration of custom implants for large acetabular defects. Journal of Orthopaedic Research 10.1002/jor.25818 <https://doi.org/10.1002/jor.25818>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10188426/1/Journal%20Orthopaedic%20Research%20-%202024%20-%20De%20Angelis%20-%20The%20role%20of%20bone%20remodeling%20in%20measuring%20migration%20of%20custom%20implants.pdf