TY - INPR N1 - Copyright © 2024 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. KW - Acetabular defect KW - biomechanical bone remodeling KW - custom implants KW - implant migration KW - Paprosky IIIB defect PB - Wiley A1 - De Angelis, Sara A1 - Di Laura, Anna A1 - Ramesh, Angelika A1 - Henckel, Johann A1 - Hart, Alister JF - Journal of Orthopaedic Research AV - public TI - The role of bone remodeling in measuring migration of custom implants for large acetabular defects Y1 - 2024/02/26/ SN - 0736-0266 ID - discovery10188426 UR - http://dx.doi.org/10.1002/jor.25818 N2 - In revision total hip arthroplasty, achieving robust fixation is difficult and implant movement may occur over time. Bone may also rearrange around the implant as a result of mechanical loading, making the measurement of migration challenging. The study aimed to quantify changes in bone shape and implant position 1 year following acetabular reconstruction using custom three-dimensional-printed cups. This observational retrospective cohort study involved 23 patients with Paprosky type IIIB defects. Postop computed tomography scans taken within 1 week of surgery and at 1-year postsurgery were co-registered and analyzed. Three co-registration strategies were implemented including bone-to-bone and implant-to-implant. (1) Co-registration of the ipsilateral innominate bone (diseased anatomy) was used to measure changes in implant position. (2) Co-registration of the implant was carried out to quantify changes in the ipsilateral innominate bone shape. (3) Co-registration of the contralateral innominate bone (nondiseased anatomy) was performed to measure changes in the ipsilateral innominate bone shape and implant position. The median centroid distances (interquartile range [IQR]) were 2.3?mm (IQR: 3.7?1.7?mm) for changes in implant position, 2.4?mm (IQR: 3.6?1.6?mm) for changes in ipsilateral innominate bone shape, and 3.7?mm (IQR: 4.6?3.5?mm) for changes in ipsilateral innominate bone shape and implant position. Following acetabular reconstruction, implant movements and periprosthetic bone remodeling are physiological and of a similar extent. Surgeons and engineers should consider this when performing implant monitoring in these patients. ER -