eprintid: 10188168
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/18/81/68
datestamp: 2024-02-29 09:51:53
lastmod: 2024-10-28 15:24:32
status_changed: 2024-02-29 09:51:53
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Zarnegar, Roxaneh
creators_name: Vounta, Angeliki
creators_name: Li, Qiuyuan
creators_name: Ghoreishizadeh, Sara
title: Nociception related biomolecules in the adult human saliva: a scoping review with additional quantitative focus on cortisol
ispublished: inpress
subjects: RNOH
divisions: UCL
divisions: B04
divisions: C05
divisions: F46
keywords: Acute pain; Biomarkers; Experimental pain; 
Induced Pain; Saliva; 
scoping review
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Nociception related salivary biomolecules can be useful patients who are not able to self-report pain. We present the existing evidence on this topic using the PRISMA-ScR guidelines and a more focused analysis of cortisol change after cold pain induction using the direction of effect analysis combined with risk of bias analysis using ROBINS-I. Five data bases were searched systematically for articles on adults with acute pain secondary to disease, injury or experimentally induced pain. 43 articles met the inclusion criteria for the general review and 11 of these were included in the cortisol-cold pain analysis. Salivary melatonin, kallikreins, pro-inflammatory cytokines, soluable TNFαreceptor II, secretory IgA, testosterone, salivary α-amylase and, most commonly, cortisol have been studied in relation to acute pain. There is greatest information about cortisol and sAA which both rise after cold pain when compared with other modalities. Where participants have been subjected to both pain and stress, stress is consistently a more reliable predictor of salivary biomarker change than pain. In conclusion, there remain considerable challenges in identifying biomarkers that can be used in clinical practice to guide the measurement of nociception and treatment of pain. Standardization of methodology and researchers’ greater awareness of the factors that affect salivary biomolecule concentrations are needed to improve our understanding of this field towards creating a clinically relevant body of evidence.
date: 2024-02-22
date_type: published
publisher: SAGE Publications
official_url: http://dx.doi.org/10.1177/17448069241237121
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2252122
doi: 10.1177/17448069241237121
medium: Print-Electronic
lyricists_name: Ghoreishizadeh, Seyedeh
lyricists_id: SSGHO93
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
funding_acknowledgements: 204841/Z/16/Z [Wellcome Trust]
full_text_status: public
publication: Molecular Pain
event_location: United States
issn: 1744-8069
citation:        Zarnegar, Roxaneh;    Vounta, Angeliki;    Li, Qiuyuan;    Ghoreishizadeh, Sara;      (2024)    Nociception related biomolecules in the adult human saliva: a scoping review with additional quantitative focus on cortisol.                   Molecular Pain        10.1177/17448069241237121 <https://doi.org/10.1177/17448069241237121>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10188168/1/Ghoreishizadeh_Nociception%20related%20biomolecules%20in%20the%20adult%20human%20saliva_AAM.pdf