TY  - JOUR
Y1  - 2024/02//
N2  - INTRODUCTION: Obesity increases risks of male infertility, but bariatric surgery does not improve semen quality. Recent uncontrolled studies suggest that a low-energy diet (LED) improves semen quality. Further evaluation within a randomized, controlled setting is warranted. METHODS: Men with obesity (18-60 years) with normal sperm concentration (normal count) (n = 24) or oligozoospermia (n = 43) were randomized 1:1 to either 800 kcal/day LED for 16 weeks or control, brief dietary intervention (BDI) with 16 weeks' observation. Semen parameters were compared at baseline and 16 weeks. RESULTS: Mean age of men with normal count was 39.4 ± 6.4 in BDI and 40.2 ± 9.6 years in the LED group. Mean age of men with oligozoospermia was 39.5 ± 7.5 in BDI and 37.7 ± 6.6 years in the LED group. LED caused more weight loss than BDI in men with normal count (14.4 vs 6.3 kg; P < .001) and men with oligozoospermia (17.6 vs 1.8 kg; P < .001). Compared with baseline, in men with normal count total motility (TM) increased 48 ± 17% to 60 ± 10% (P < .05) after LED, and 52 ± 8% to 61 ± 6% (P < .0001) after BDI; progressive motility (PM) increased 41 ± 16% to 53 ± 10% (P < .05) after LED, and 45 ± 8% to 54 ± 65% (P < .001) after BDI. In men with oligozoospermia compared with baseline, TM increased 35% [26] to 52% [16] (P < .05) after LED, and 43% [28] to 50% [23] (P = .0587) after BDI; PM increased 29% [23] to 46% [18] (P < .05) after LED, and 33% [25] to 44% [25] (P < .05) after BDI. No differences in postintervention TM or PM were observed between LED and BDI groups in men with normal count or oligozoospermia. CONCLUSION: LED or BDI may be sufficient to improve sperm motility in men with obesity. The effects of paternal dietary intervention on fertility outcomes requires investigation.
JF  - The Journal of Clinical Endocrinology & Metabolism
N1  - © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
VL  - 109
ID  - discovery10188038
UR  - http://dx.doi.org/10.1210/clinem/dgad523
PB  - ENDOCRINE SOC
TI  - Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity
AV  - public
A1  - Sharma, Aditi
A1  - Papanikolaou, Nikoleta
A1  - Abou Sherif, Sara
A1  - Dimakopolou, Anastasia
A1  - Thaventhiran, Thilipan
A1  - Go, Cara
A1  - Entwistle, Olivia Holtermann
A1  - Brown, Adrian
A1  - Luo, Rong
A1  - Jha, Rama
A1  - Prakash, Anavi
A1  - Khalifa, Dalia
A1  - Lewis, Hannah
A1  - Ramaraju, Sruthi
A1  - Leeds, Anthony R
A1  - Chahal, Harvinder
A1  - Purkayastha, Sanjay
A1  - Henkel, Ralf
A1  - Minhas, Sukhbinder
A1  - Frost, Gary
A1  - Dhillo, Waljit S
A1  - Jayasena, Channa N
SP  - 449
SN  - 0021-972X
EP  - 460
IS  - 2
KW  - male reproduction
KW  -  male fertility
KW  -  obesity
KW  -  spermatogenesis
KW  -  weight loss
KW  -  sperm quality
ER  -