eprintid: 10187922
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/18/79/22
datestamp: 2024-02-27 12:09:51
lastmod: 2024-02-27 12:09:51
status_changed: 2024-02-27 12:09:51
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Phillips, Thomas
creators_name: Harris, Scott
creators_name: Aiyegbusi, Olalekan Lee
creators_name: Lucas, Bethany
creators_name: Benavente, Melissa
creators_name: Roderick, Paul J
creators_name: Cockwell, Paul
creators_name: Kalra, Philip A
creators_name: Wheeler, David C
creators_name: Taal, Maarten W
creators_name: Fraser, Simon DS
title: Potentially modifiable factors associated with health-related quality of life among people with chronic kidney disease: baseline findings from the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
keywords: Chronic kidney disease, health-related quality of life, population health, quality of life
note: Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Background:
Many non-modifiable factors are associated with poorer health-related quality of life (HRQoL) experienced by people with chronic kidney disease (CKD). We hypothesize that potentially modifiable factors for poor HRQoL can be identified among CKD patients, providing potential targets for intervention.
//
Method:
The National Unified Renal Translational Research Enterprise Chronic Kidney Disease (NURTuRE-CKD) cohort study recruited 2996 participants from nephrology centres with all stages of non-dialysis-dependent CKD. Baseline data collection for sociodemographic, anthropometric, biochemical and clinical information, including Integrated Palliative care Outcome Scale renal, Hospital Anxiety and Depression score (HADS) and the 5-level EuroQol-5D (EQ-5D-5L) as HRQoL measure, took place between 2017 and 2019. EQ-5D-5L dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) were mapped to an EQ-5D-3L value set to derive index value. Multivariable mixed effects regression models, adjusted for known factors affecting HRQoL with recruitment region as a random effect, were fit to assess potentially modifiable factors associated with index value (linear) and within each dimension (logistic).
//
Results:
Among the 2958/2996 (98.7%) participants with complete EQ-5D data, 2201 (74.4%) reported problems in at least one EQ-5D-5L dimension. Multivariable linear regression identified independent associations between poorer HRQoL (EQ-5D-3L index value) and obesity (body mass index ≥30.0 kg/m2, β −0.037, 95% CI −0.058 to −0.016, P = .001), HADS depression score ≥8 (β −0.159, −0.182 to −0.137, P < .001), anxiety score ≥8 (β −0.090, −0.110 to −0.069, P < .001), taking ≥10 medications (β −0.065, −0.085 to −0.046, P < .001), sarcopenia (β −0.062, −0.080 to −0.043, P < .001) haemoglobin <100 g/L (β −0.047, −0.085 to −0.010, P = .012) and pain (β −0.134, −0.152 to −0.117, P < .001). Smoking and prescription of prednisolone independently associated with problems in self-care and usual activities respectively. Renin–angiotensin system inhibitor (RASi) prescription associated with fewer problems with mobility and usual activities.
//
Conclusion:
Potentially modifiable factors including obesity, pain, depression, anxiety, anaemia, polypharmacy, smoking, steroid use and sarcopenia associated with poorer HRQoL in this cohort, whilst RASi use was associated with better HRQoL in two dimensions.
date: 2024-02
date_type: published
publisher: OXFORD UNIV PRESS
official_url: http://dx.doi.org/10.1093/ckj/sfae010
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2245264
doi: 10.1093/ckj/sfae010
medium: Electronic-eCollection
pii: sfae010
lyricists_name: Wheeler, David
lyricists_id: DWHEE12
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: RP/005/20210728 [NURTuRE-CKD HRQoL through a Kidney Research UK (KRUK)]; [NURTuRE-CKD cohort study]
full_text_status: public
publication: Clinical Kidney Journal
volume: 17
number: 2
article_number: sfae010
pages: 16
event_location: England
issn: 2048-8505
citation:        Phillips, Thomas;    Harris, Scott;    Aiyegbusi, Olalekan Lee;    Lucas, Bethany;    Benavente, Melissa;    Roderick, Paul J;    Cockwell, Paul;                 ... Fraser, Simon DS; + view all <#>        Phillips, Thomas;  Harris, Scott;  Aiyegbusi, Olalekan Lee;  Lucas, Bethany;  Benavente, Melissa;  Roderick, Paul J;  Cockwell, Paul;  Kalra, Philip A;  Wheeler, David C;  Taal, Maarten W;  Fraser, Simon DS;   - view fewer <#>    (2024)    Potentially modifiable factors associated with health-related quality of life among people with chronic kidney disease: baseline findings from the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort.                   Clinical Kidney Journal , 17  (2)    , Article sfae010.  10.1093/ckj/sfae010 <https://doi.org/10.1093/ckj%2Fsfae010>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10187922/1/sfae010.pdf