TY  - JOUR
TI  - Potentially modifiable factors associated with health-related quality of life among people with chronic kidney disease: baseline findings from the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort
EP  - 16
AV  - public
Y1  - 2024/02//
ID  - discovery10187922
N2  - Background:
Many non-modifiable factors are associated with poorer health-related quality of life (HRQoL) experienced by people with chronic kidney disease (CKD). We hypothesize that potentially modifiable factors for poor HRQoL can be identified among CKD patients, providing potential targets for intervention.
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Method:
The National Unified Renal Translational Research Enterprise Chronic Kidney Disease (NURTuRE-CKD) cohort study recruited 2996 participants from nephrology centres with all stages of non-dialysis-dependent CKD. Baseline data collection for sociodemographic, anthropometric, biochemical and clinical information, including Integrated Palliative care Outcome Scale renal, Hospital Anxiety and Depression score (HADS) and the 5-level EuroQol-5D (EQ-5D-5L) as HRQoL measure, took place between 2017 and 2019. EQ-5D-5L dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) were mapped to an EQ-5D-3L value set to derive index value. Multivariable mixed effects regression models, adjusted for known factors affecting HRQoL with recruitment region as a random effect, were fit to assess potentially modifiable factors associated with index value (linear) and within each dimension (logistic).
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Results:
Among the 2958/2996 (98.7%) participants with complete EQ-5D data, 2201 (74.4%) reported problems in at least one EQ-5D-5L dimension. Multivariable linear regression identified independent associations between poorer HRQoL (EQ-5D-3L index value) and obesity (body mass index ?30.0 kg/m2, ? ?0.037, 95% CI ?0.058 to ?0.016, P = .001), HADS depression score ?8 (? ?0.159, ?0.182 to ?0.137, P < .001), anxiety score ?8 (? ?0.090, ?0.110 to ?0.069, P < .001), taking ?10 medications (? ?0.065, ?0.085 to ?0.046, P < .001), sarcopenia (? ?0.062, ?0.080 to ?0.043, P < .001) haemoglobin <100 g/L (? ?0.047, ?0.085 to ?0.010, P = .012) and pain (? ?0.134, ?0.152 to ?0.117, P < .001). Smoking and prescription of prednisolone independently associated with problems in self-care and usual activities respectively. Renin?angiotensin system inhibitor (RASi) prescription associated with fewer problems with mobility and usual activities.
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Conclusion:
Potentially modifiable factors including obesity, pain, depression, anxiety, anaemia, polypharmacy, smoking, steroid use and sarcopenia associated with poorer HRQoL in this cohort, whilst RASi use was associated with better HRQoL in two dimensions.
PB  - OXFORD UNIV PRESS
KW  - Chronic kidney disease
KW  -  health-related quality of life
KW  -  population health
KW  -  quality of life
VL  - 17
N1  - Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
IS  - 2
SN  - 2048-8505
UR  - http://dx.doi.org/10.1093/ckj/sfae010
JF  - Clinical Kidney Journal
A1  - Phillips, Thomas
A1  - Harris, Scott
A1  - Aiyegbusi, Olalekan Lee
A1  - Lucas, Bethany
A1  - Benavente, Melissa
A1  - Roderick, Paul J
A1  - Cockwell, Paul
A1  - Kalra, Philip A
A1  - Wheeler, David C
A1  - Taal, Maarten W
A1  - Fraser, Simon DS
ER  -