<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10187631> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/title> "Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/abstract> "Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome. However, the underlying mechanism remains unclear. Exploring the mechanisms of MDSCs generation may provide therapeutic targets for improving immune status in sepsis. Here, a sepsis mouse model is established by cecal ligation and perforation. Bone marrow cells at different sepsis time points are harvested to detect the proportion of MDSCs and search for differentially expressed genes by RNA-sequence. In lethal models of sepsis, polymorphonuclear-MDSCs (PMN-MDSCs) decrease in early but increase and become activated in late sepsis, which is contrary to the expression of metastasis-associated lung adenocarcinoma transcript 1 (Malat1). In vivo, Malat1 inhibitor significantly increases the mortality in mice with late sepsis. And in vitro, Malat1 down-regulation increases the proportion of PMN-MDSCs and enhanced its immunosuppressive ability. Mechanistically, Malat1 limits the differentiation of PMN-MDSCs by accelerating the degradation of phosphorylated STAT3. Furthermore, Stattic, an inhibitor of STAT3 phosphorylation, improves the survival of septic mice by inhibiting PMN-MDSCs. Overall, the study identifies a novel insight into the mechanism of sepsis-induced MDSCs and provides more evidence for targeting MDSCs in the treatment of sepsis."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/date> "2024" .
<https://discovery.ucl.ac.uk/id/document/1714907> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/volume> "20" .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/issue> "4" .
<https://discovery.ucl.ac.uk/id/org/ext-b63731780d3efd4bbbe96d017ffb3225> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-b63731780d3efd4bbbe96d017ffb3225> <http://xmlns.com/foaf/0.1/name> "Ivyspring International Publisher"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-b63731780d3efd4bbbe96d017ffb3225> .
<https://discovery.ucl.ac.uk/id/publication/ext-010580fb001598ca24c2b55a14ec50a1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-010580fb001598ca24c2b55a14ec50a1> <http://xmlns.com/foaf/0.1/name> "International Journal of Biological Sciences"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-010580fb001598ca24c2b55a14ec50a1> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> .
<https://discovery.ucl.ac.uk/id/eprint/10187631> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187631#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187631#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> .
<https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> <http://xmlns.com/foaf/0.1/givenName> "Yao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-698787cfe3325a811755f2962c17bcd8> <http://xmlns.com/foaf/0.1/name> "Yao Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> <http://xmlns.com/foaf/0.1/givenName> "Guoping"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> <http://xmlns.com/foaf/0.1/familyName> "Lu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ab940f6b91cc1b5b43c7dcf603e7291> <http://xmlns.com/foaf/0.1/name> "Guoping Lu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> <http://xmlns.com/foaf/0.1/givenName> "Kexin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9313f6a0894b02a7c225f5698fa68a93> <http://xmlns.com/foaf/0.1/name> "Kexin Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> <http://xmlns.com/foaf/0.1/givenName> "Xiuchuan Lucas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> <http://xmlns.com/foaf/0.1/familyName> "Hu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7952c732656a100e4196e88fc7f38e21> <http://xmlns.com/foaf/0.1/name> "Xiuchuan Lucas Hu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> <http://xmlns.com/foaf/0.1/givenName> "Ting"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> <http://xmlns.com/foaf/0.1/familyName> "Zhu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bcf5a54d036b06e52bc006961af540b> <http://xmlns.com/foaf/0.1/name> "Ting Zhu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> <http://xmlns.com/foaf/0.1/givenName> "Jingjing"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a1f1e7256fe5ff8984c1bcc456e2266> <http://xmlns.com/foaf/0.1/name> "Jingjing Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> <http://xmlns.com/foaf/0.1/givenName> "Yaodong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55e2b5ea6cfa928752fcef58a2c5846c> <http://xmlns.com/foaf/0.1/name> "Yaodong Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> <http://xmlns.com/foaf/0.1/givenName> "Zhenhao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> <http://xmlns.com/foaf/0.1/familyName> "Yu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9b25aecdfafe13c4d85ee109485bc69> <http://xmlns.com/foaf/0.1/name> "Zhenhao Yu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> <http://xmlns.com/foaf/0.1/givenName> "Yufeng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> <http://xmlns.com/foaf/0.1/familyName> "Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b12b9d5b6378396b8384fbc003db3b6> <http://xmlns.com/foaf/0.1/name> "Yufeng Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> <http://xmlns.com/foaf/0.1/givenName> "Jiayun"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> <http://xmlns.com/foaf/0.1/familyName> "Ying"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5afc4ff4eaa0b50ac55ec6dbde4dd231> <http://xmlns.com/foaf/0.1/name> "Jiayun Ying"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> <http://xmlns.com/foaf/0.1/givenName> "Caiyan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2805459827a0fd5443344312c38c5673> <http://xmlns.com/foaf/0.1/name> "Caiyan Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> <http://xmlns.com/foaf/0.1/givenName> "Tingyan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af4b210d76a3b99e128254cfe7ba56bb> <http://xmlns.com/foaf/0.1/name> "Tingyan Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
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