eprintid: 10187576
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/18/75/76
datestamp: 2024-02-22 09:58:28
lastmod: 2024-02-22 09:58:28
status_changed: 2024-02-22 09:58:28
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Pirouz, Arash
creators_name: Papakonstantinou, Ioannis
creators_name: Michalska, Martyna
title: Antimicrobial mechanisms of nanopatterned surfaces—a developing story
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F46
divisions: F45
keywords: Bioinspired, biomimetic, biofouling, antimicrobial mechanisms, mechanobactericidal surfaces, nanopatterns, driving force
note: Copyright © 2024 Pirouz, Papakonstantinou and Michalska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
abstract: Whilst it is now well recognized that some natural surfaces such as seemingly fragile insect wings possess extraordinary antimicrobial properties, a quest to engineer similar nanopatterned surfaces (NPSs) is ongoing. The stake is high as biofouling impacts critical infrastructure leading to massive social and economic burden with an antimicrobial resistance (AMR) issue at the forefront. AMR is one of the most imminent health challenges the world is facing today. Here, in the effort to find more sustainable solutions, the NPSs are proposed as highly promising technology as their antimicrobial activity arises from the topographical features, which could be realized on multiple material surfaces. To fully exploit these potentials however, it is crucial to mechanistically understand the underlying killing pathways. Thus far, several mechanisms have been proposed, yet they all have one thing in common. The antimicrobial process is initiated with bacteria contacting nanopatterns, which then imposes mechanical stress onto bacterial cell wall. Hence, the activity is called “mechano-bactericidal”. From this point on, however, the suggested mechanisms start to diverge partly due to our limited understanding of force interactions at the interface. The aim of this mini review is to analyze the state-of-the-art in proposed killing mechanisms by categorizing them based on the characteristics of their driving force. We also highlight the current gaps and possible future directions in investigating the mechanisms, particularly by shifting towards quantification of forces at play and more elaborated biochemical assays, which can aid validating the current hypotheses.
date: 2024
date_type: published
publisher: Frontiers Media SA
official_url: http://dx.doi.org/10.3389/fchem.2024.1354755
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2247455
doi: 10.3389/fchem.2024.1354755
medium: Electronic-eCollection
pii: 1354755
lyricists_name: Papakonstantinou, Ioannis
lyricists_name: Michalska, Martyna
lyricists_id: IPAPA54
lyricists_id: MMICH02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Frontiers in Chemistry
volume: 12
article_number: 1354755
event_location: Switzerland
issn: 2296-2646
citation:        Pirouz, Arash;    Papakonstantinou, Ioannis;    Michalska, Martyna;      (2024)    Antimicrobial mechanisms of nanopatterned surfaces—a developing story.                   Frontiers in Chemistry , 12     , Article 1354755.  10.3389/fchem.2024.1354755 <https://doi.org/10.3389/fchem.2024.1354755>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10187576/1/fchem-12-1354755.pdf