<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10187003> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/title> "Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/abstract> "It has been reported that some mutations in the genome of hepatitis B virus (HBV) may predict the outcome of the virus infection. However, evolutionary data derived from long-term longitudinal analysis of entire HBV genomes using next generation sequencing (NGS) remain rare. In this study, serum samples were collected from asymptomatic hepatitis B surface antigen (HBsAg) carriers from a long-term prospective cohort. The entire HBV genome was amplified by polymerase chain reaction (PCR) and sequenced using NGS. Twenty-eight time series serum samples from nine subjects were successfully analysed. The Shannon entropy (Sn) ranged from 0 to 0.89, with a median value of 0.76, and the genetic diversity (D) ranged from 0 to 0.013, with a median value of 0.004. Intrahost HBV viral evolutionary rates ranged from 2.39E-04 to 3.11E-03. Double mutations at nt1762(A → T) and 1764(G → A) and a stop mutation at nt1896(G → A) were seen in all sequences from subject BO129 in 2007. However, in 2019, most sequences were wild type at these positions. Deletions between nt 2920–3040 were seen in all sequences from subject TS115 in 2007 and 2013 but these were not present in 2004 or 2019. Some sequences from subject CC246 had predicted escape substitutions (T123N, G145R) in the surface protein in 2004, 2013 and 2019 but none of the sequences from 2007 had these changes. In conclusion, HBV mutations may revert to wild type in natural infection. Clinicians should be wary of predicting long-term prognoses on the basis of the presence of mutations."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/date> "2022-01-24" .
<https://discovery.ucl.ac.uk/id/document/1710104> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/volume> "97" .
<https://discovery.ucl.ac.uk/id/org/ext-dce96e9e054f6e86d2f2580e274b0171> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-dce96e9e054f6e86d2f2580e274b0171> <http://xmlns.com/foaf/0.1/name> "ELSEVIER"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-dce96e9e054f6e86d2f2580e274b0171> .
<https://discovery.ucl.ac.uk/id/publication/ext-c8c51bdc91014ca92d26c5550c0b7e9e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-c8c51bdc91014ca92d26c5550c0b7e9e> <http://xmlns.com/foaf/0.1/name> "Infection, Genetics and Evolution"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-c8c51bdc91014ca92d26c5550c0b7e9e> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> .
<https://discovery.ucl.ac.uk/id/eprint/10187003> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10187003#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10187003#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> .
<https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> <http://xmlns.com/foaf/0.1/givenName> "Lu-Juan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a64e27e62c8995727a3f6f43722805cf> <http://xmlns.com/foaf/0.1/name> "Lu-Juan Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> <http://xmlns.com/foaf/0.1/givenName> "Qin-Yan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-037f6619264fc40e48302717638ec92a> <http://xmlns.com/foaf/0.1/name> "Qin-Yan Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> <http://xmlns.com/foaf/0.1/givenName> "Xue-Yan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7884dc27ee767f77b38e844f87f46e9> <http://xmlns.com/foaf/0.1/name> "Xue-Yan Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> <http://xmlns.com/foaf/0.1/givenName> "Chao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ca1b7338ec633b2862ddf9b4fdb270e> <http://xmlns.com/foaf/0.1/name> "Chao Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> <http://xmlns.com/foaf/0.1/givenName> "Li-Ping"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> <http://xmlns.com/foaf/0.1/familyName> "Hu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-64be8bb78f002ca7a66504beae4fdfa7> <http://xmlns.com/foaf/0.1/name> "Li-Ping Hu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> <http://xmlns.com/foaf/0.1/givenName> "Hui-Hua"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> <http://xmlns.com/foaf/0.1/familyName> "Jia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c1f0a60820740449ecd7e0b523f1574> <http://xmlns.com/foaf/0.1/name> "Hui-Hua Jia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> <http://xmlns.com/foaf/0.1/givenName> "Tim J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> <http://xmlns.com/foaf/0.1/familyName> "Harrison"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9f7e2f7ebad3fd6b0b23c248744dc3d> <http://xmlns.com/foaf/0.1/name> "Tim J Harrison"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> <http://xmlns.com/foaf/0.1/givenName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> <http://xmlns.com/foaf/0.1/familyName> "Wu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15df3317aa6a52e812d279a92e535ec5> <http://xmlns.com/foaf/0.1/name> "Li Wu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> <http://xmlns.com/foaf/0.1/givenName> "Zhong-Liao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> <http://xmlns.com/foaf/0.1/familyName> "Fang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69765032e772310559301a6c0cfd5e37> <http://xmlns.com/foaf/0.1/name> "Zhong-Liao Fang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> <http://xmlns.com/foaf/0.1/givenName> "J Brooks"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> <http://xmlns.com/foaf/0.1/familyName> "Jackson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95fcc1756c41f1b3917478dc00456709> <http://xmlns.com/foaf/0.1/name> "J Brooks Jackson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> <http://xmlns.com/foaf/0.1/givenName> "Yun-Liang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> <http://xmlns.com/foaf/0.1/familyName> "Shi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-260e863021ce208089dd41ece85b7ab5> <http://xmlns.com/foaf/0.1/name> "Yun-Liang Shi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> <http://xmlns.com/foaf/0.1/givenName> "Xiang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> <http://xmlns.com/foaf/0.1/familyName> "He"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-26d7229df3e08b0111dde80963aa38c4> <http://xmlns.com/foaf/0.1/name> "Xiang He"^^<http://www.w3.org/2001/XMLSchema#string> .
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