TY  - INPR
ID  - discovery10186856
AV  - public
A1  - Westensee, Isabella Nymann
A1  - Thomsen, Karen Louise
A1  - Mookerjee, Rajeshwar Prosad
A1  - Städler, Brigitte
KW  - EUK compounds
KW  -  antioxidants
KW  -  hepatocytes
KW  -  hydrogels
KW  -  reactive oxygen species
SN  - 2701-0198
Y1  - 2024/01/28/
UR  - http://dx.doi.org/10.1002/adbi.202300547
PB  - Wiley
N2  - Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.
TI  - Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells
N1  - © 2024 The Authors. Advanced Biology published by Wiley-VCH GmbH

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
JF  - Advanced Biology
ER  -