eprintid: 10186730
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/18/67/30
datestamp: 2024-02-07 16:25:06
lastmod: 2024-02-07 16:25:06
status_changed: 2024-02-07 16:25:06
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Wernig, F
creators_name: Dunin-Borkowska, A
creators_name: Frisiras, A
creators_name: Khoo, B
creators_name: Todd, J
creators_name: Di Marco, A
creators_name: Palazzo, FF
creators_name: Barnes, SC
creators_name: Tan, TM
creators_name: Meeran, K
creators_name: Alsafi, A
title: Adrenal Vein Sampling: Does the Location of the Non-adrenal Venous Sample Matter?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
keywords: Adrenal, Adrenal vein sampling, Conn’s, Hypertension, Primary aldosteronism, Primary hyperaldosteronism
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users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
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abstract: Purpose: Adrenal vein sampling (AVS) is used to lateralise and differentiate unilateral from bilateral aldosterone production in primary aldosteronism. The adrenal venous samples are standardised to a peripheral or low inferior vena cava (IVC) sample and compared. It is unknown whether the location of the non-adrenal sample affects the results. This study compares AVS results standardised to the low IVC and right external iliac vein (REIV). Methods: Patients who underwent AVS between March 2021 and May 2023 were included. All procedures were undertaken by a single operator (AA). Demographic data and AVS results were collected from patients’ electronic records. Catheterisation success and lateralisation were assessed using both low IVC and REIV samples. Equivalence test was used to compare the cortisol and aldosterone levels. Results: Eighty-one patients, (M: F = 38:43), aged between 29 and 74 were included. Bilateral successful adrenal vein cannulation was achieved in 79/81 (97.5%) cases. The mean cortisol levels from the REIV were statistically equivalent although there was a small and not biologically significant difference from the low IVC (respective geometric means 183 nmol/l vs. 185 nmol/l, p = 0.015). This small difference in cortisol may be due to accessory adrenal venous drainage into the IVC. The aldosterone and aldosterone/cortisol ratios were statistically equivalent. There was no discordance in selectivity or lateralisation when the IVC or REIV measurements were used. Conclusion: The IVC and REIV samples may be used interchangeably during AVS. Graphical Abstract: [Figure not available: see fulltext.].
date: 2024-01-11
date_type: published
publisher: Springer Science and Business Media LLC
official_url: http://dx.doi.org/10.1007/s00270-023-03647-z
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2141480
doi: 10.1007/s00270-023-03647-z
medium: Print-Electronic
pii: 10.1007/s00270-023-03647-z
lyricists_name: Khoo, Bernard
lyricists_id: BKHOO30
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: CardioVascular and Interventional Radiology
volume: 47
pagerange: 194-199
event_location: United States
citation:        Wernig, F;    Dunin-Borkowska, A;    Frisiras, A;    Khoo, B;    Todd, J;    Di Marco, A;    Palazzo, FF;                 ... Alsafi, A; + view all <#>        Wernig, F;  Dunin-Borkowska, A;  Frisiras, A;  Khoo, B;  Todd, J;  Di Marco, A;  Palazzo, FF;  Barnes, SC;  Tan, TM;  Meeran, K;  Alsafi, A;   - view fewer <#>    (2024)    Adrenal Vein Sampling: Does the Location of the Non-adrenal Venous Sample Matter?                   CardioVascular and Interventional Radiology , 47    pp. 194-199.    10.1007/s00270-023-03647-z <https://doi.org/10.1007/s00270-023-03647-z>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10186730/1/Khoo_Adrenal%20Vein%20Sampling-%20Does%20the%20Location%20of%20the%20Non-adrenal%20Venous%20Sample%20Matter_VoR.pdf