<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/dc/terms/title> "Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Only a small group of patients with glioblastoma multiforme (GBM) survives more than 36 months, so-called long-term survivors. Recent studies have shown that chromosomal instability (CIN) plays a prognostic and predictive role among different cancer types. Here, we compared histological (chromosome missegregation) and bioinformatic metrics (CIN signatures) of CIN in tumors of GBM typical survivors (≤36 months overall survival), GBM long-term survivors and isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas. METHODS: Tumor sections of all gliomas were examined for anaphases and chromosome missegregation. Further CIN signature activity analysis in the The Cancer Genome Atlas (TCGA)-GBM cohort was performed. RESULTS: Our data show that chromosome missegregation is pervasive in high grade gliomas and is not different between the 3 groups. We find only limited evidence of altered CIN levels in tumors of GBM long-term survivors relative to the other groups, since a significant depletion in CIN signature 11 relative to GBM typical survivors was the only alteration detected. In contrast, within IDH-mutant grade 4 astrocytomas we detected a significant enrichment of CIN signature 5 and 10 activities and a depletion of CIN signature 1 activity relative to tumors of GBM typical survivors. CONCLUSIONS: Our data suggest that CIN is pervasive in high grade gliomas, however this is unlikely to be a major contributor to the phenomenon of long-term survivorship in GBM. Nevertheless, further evaluation of specific types of CIN (signatures) could have prognostic value in patients suffering from grade 4 gliomas."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/dc/terms/date> "2023" .
<https://discovery.ucl.ac.uk/id/document/1685477> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/ontology/bibo/volume> "13" .
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<https://discovery.ucl.ac.uk/id/org/ext-37c4d1a7c4dac33c8579066043b6c321> <http://xmlns.com/foaf/0.1/name> "Frontiers Media SA"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10186291#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-44d6604495883c275dcc542f163a1d40> .
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<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10186291#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10186291#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fd30cd17b25c65730e807af3bb0576f6> .
<https://discovery.ucl.ac.uk/id/eprint/10186291> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10186291#authors> .
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<https://discovery.ucl.ac.uk/id/person/ext-41f54f81baead436317fc058bac0d63d> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-41f54f81baead436317fc058bac0d63d> <http://xmlns.com/foaf/0.1/familyName> "den Braber"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-41f54f81baead436317fc058bac0d63d> <http://xmlns.com/foaf/0.1/name> "M den Braber"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564fe224c8ae2f0b8e6b000c4c5a06c2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-564fe224c8ae2f0b8e6b000c4c5a06c2> <http://xmlns.com/foaf/0.1/givenName> "JKH"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564fe224c8ae2f0b8e6b000c4c5a06c2> <http://xmlns.com/foaf/0.1/familyName> "Spoor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564fe224c8ae2f0b8e6b000c4c5a06c2> <http://xmlns.com/foaf/0.1/name> "JKH Spoor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49582b1eef18106e910989f6d4126fc5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-49582b1eef18106e910989f6d4126fc5> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49582b1eef18106e910989f6d4126fc5> <http://xmlns.com/foaf/0.1/familyName> "Bartkova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49582b1eef18106e910989f6d4126fc5> <http://xmlns.com/foaf/0.1/name> "J Bartkova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6968a2c97ae1eab64a2a59b7b1c03e84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6968a2c97ae1eab64a2a59b7b1c03e84> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6968a2c97ae1eab64a2a59b7b1c03e84> <http://xmlns.com/foaf/0.1/familyName> "Pennycuick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6968a2c97ae1eab64a2a59b7b1c03e84> <http://xmlns.com/foaf/0.1/name> "A Pennycuick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> <http://xmlns.com/foaf/0.1/familyName> "Leenstra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a117521ce5211c5c83da464175bf2d81> <http://xmlns.com/foaf/0.1/name> "S Leenstra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b1b6c6284985d7faeb2cfa391df4a4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-07b1b6c6284985d7faeb2cfa391df4a4> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b1b6c6284985d7faeb2cfa391df4a4> <http://xmlns.com/foaf/0.1/familyName> "Bartek"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b1b6c6284985d7faeb2cfa391df4a4> <http://xmlns.com/foaf/0.1/name> "J Bartek"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-55f9fa13616ea46eab0d8713279cce14> <http://xmlns.com/foaf/0.1/name> "CMF Dirven"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-0460c9e4892422e304104b7dee5c3528> <http://xmlns.com/foaf/0.1/familyName> "van Dis"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-44d6604495883c275dcc542f163a1d40> <http://xmlns.com/foaf/0.1/familyName> "van den Bosch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-44d6604495883c275dcc542f163a1d40> <http://xmlns.com/foaf/0.1/name> "TPP van den Bosch"^^<http://www.w3.org/2001/XMLSchema#string> .
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