eprintid: 10185743
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/18/57/43
datestamp: 2024-01-18 15:04:50
lastmod: 2024-01-18 15:04:50
status_changed: 2024-01-18 15:04:50
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Simcock, Ian C
creators_name: Shelmerdine, Susan C
creators_name: Hutchinson, John Ciaran
creators_name: Sebire, Neil J
creators_name: Arthurs, Owen J
title: Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G26
divisions: G25
keywords: Micro-CT, fetal, potassium tri-iodide, immersion time
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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abstract: Objectives


                  The aim of this study was to evaluate the length of time required to achieve full iodination using potassium tri-iodide as a contrast agent, prior to human fetal postmortem microfocus computed tomography (micro-CT) imaging.


               
               
                  Methods


                  Prospective assessment of optimal contrast iodination was conducted across 157 human fetuses (postmortem weight range 2-298 g; gestational age range 12-37 weeks), following micro-CT imaging. Simple linear regression was conducted to analyse which fetal demographic factors could produce the most accurate estimate for optimal iodination time.


               
               
                  Results


                  Postmortem body weight (r2 = 0.6435) was better correlated with iodination time than gestational age (r2 = 0.1384), producing a line of best fit, y = [0.0304 × body weight (g)] − 2.2103. This can be simplified for clinical use whereby immersion time (days) = [0.03 × body weight (g)] − 2.2. Using this formula, for example, a 100-g fetus would take 5.2 days to reach optimal contrast enhancement.


               
               
                  Conclusions


                  The simplified equation can now be used to provide estimation times for fetal contrast preparation time prior to micro-CT imaging and can be used to manage service throughput and parental expectation for return of their fetus.


               
               
                  Advances in knowledge


                  A simple equation from empirical data can now be used to estimate preparation time for human fetal postmortem micro-CT imaging.
date: 2023-12-12
date_type: published
publisher: Oxford University Press (OUP)
official_url: http://dx.doi.org/10.1093/bjro/tzad006
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2139881
doi: 10.1093/bjro/tzad006
lyricists_name: Simcock, Ian
lyricists_name: Sebire, Neil
lyricists_name: Arthurs, Owen
lyricists_name: Shelmerdine, Susan
lyricists_id: ICSIM28
lyricists_id: NJSEB45
lyricists_id: OARTH57
lyricists_id: SCSHE38
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: BJR|Open
volume: 6
number: 1
article_number: tzad006
citation:        Simcock, Ian C;    Shelmerdine, Susan C;    Hutchinson, John Ciaran;    Sebire, Neil J;    Arthurs, Owen J;      (2023)    Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography.                   BJR|Open , 6  (1)    , Article tzad006.  10.1093/bjro/tzad006 <https://doi.org/10.1093/bjro%2Ftzad006>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10185743/1/tzad006.pdf