TY  - JOUR
AV  - public
Y1  - 2023/12/12/
TI  - Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography
UR  - http://dx.doi.org/10.1093/bjro/tzad006
ID  - discovery10185743
IS  - 1
N2  - Objectives


                  The aim of this study was to evaluate the length of time required to achieve full iodination using potassium tri-iodide as a contrast agent, prior to human fetal postmortem microfocus computed tomography (micro-CT) imaging.


               
               
                  Methods


                  Prospective assessment of optimal contrast iodination was conducted across 157 human fetuses (postmortem weight range 2-298?g; gestational age range 12-37?weeks), following micro-CT imaging. Simple linear regression was conducted to analyse which fetal demographic factors could produce the most accurate estimate for optimal iodination time.


               
               
                  Results


                  Postmortem body weight (r2 = 0.6435) was better correlated with iodination time than gestational age (r2 = 0.1384), producing a line of best fit, y = [0.0304 × body weight (g)] ? 2.2103. This can be simplified for clinical use whereby immersion time (days) = [0.03 × body weight (g)] ? 2.2. Using this formula, for example, a 100-g fetus would take 5.2?days to reach optimal contrast enhancement.


               
               
                  Conclusions


                  The simplified equation can now be used to provide estimation times for fetal contrast preparation time prior to micro-CT imaging and can be used to manage service throughput and parental expectation for return of their fetus.


               
               
                  Advances in knowledge


                  A simple equation from empirical data can now be used to estimate preparation time for human fetal postmortem micro-CT imaging.
VL  - 6
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
PB  - Oxford University Press (OUP)
A1  - Simcock, Ian C
A1  - Shelmerdine, Susan C
A1  - Hutchinson, John Ciaran
A1  - Sebire, Neil J
A1  - Arthurs, Owen J
JF  - BJR|Open
KW  - Micro-CT
KW  -  fetal
KW  -  potassium tri-iodide
KW  -  immersion time
ER  -