eprintid: 10185409
rev_number: 11
eprint_status: archive
userid: 699
dir: disk0/10/18/54/09
datestamp: 2024-01-15 11:22:02
lastmod: 2024-06-04 13:52:27
status_changed: 2024-01-15 11:22:02
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Lioliou, G
creators_name: BUCHANAN, I
creators_name: Astolfo, A
creators_name: Endrizzi, M
creators_name: Bate, D
creators_name: Hagen, CK
creators_name: Olivo, A
title: Framework to optimize fixed-length micro-CT systems for propagation-based phase-contrast imaging
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
note: Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License.
Further distribution of this work must maintain attribution to the author(s) and the published article’s title,
journal citation, and DOI.
abstract: A laboratory X-ray imaging system with a setup that closely resembles commercial micro-CT systems with a fixed source-to-detector distance of ∼90 cm is investigated for single distance propagation-based phase-contrast imaging and computed tomography (CT). The system had a constant source-to-detector distance, and the sample positions were optimized. Initially, a PTFE wire was imaged, both in 2D and 3D, to characterize fringe contrast and spatial resolution for different X-ray source settings and source-to-sample distances. The results were compared to calculated values based on theoretical models and to simulated (wave-optics based) results, with good agreement being found. The optimization of the imaging system is discussed. CT scans of two biological samples, a tissue-engineered esophageal scaffold and a rat heart, were then acquired at the optimum parameters, demonstrating that significant image quality improvements can be obtained with widely available components placed inside fixed-length cabinets through proper optimization of propagation-based phase-contrast.
date: 2024-02-12
date_type: published
publisher: Optical Society of America (OSA)
official_url: https://doi.org/10.1364/OE.510317
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2139456
doi: 10.1364/OE.510317
lyricists_name: Olivo, Alessandro
lyricists_id: AOLIV86
actors_name: Olivo, Alessandro
actors_id: AOLIV86
actors_role: owner
funding_acknowledgements: EP/T005408/1 [Engineering and Physical Sciences Research Council]; CiET1819/2/78 [Royal Academy of Engineering]; RF201617\16\27 [Royal Academy of Engineering]
full_text_status: public
publication: Optics Express
volume: 32
number: 4
pagerange: 4839-4856
issn: 1094-4087
citation:        Lioliou, G;    BUCHANAN, I;    Astolfo, A;    Endrizzi, M;    Bate, D;    Hagen, CK;    Olivo, A;      (2024)    Framework to optimize fixed-length micro-CT systems for propagation-based phase-contrast imaging.                   Optics Express , 32  (4)   pp. 4839-4856.    10.1364/OE.510317 <https://doi.org/10.1364/OE.510317>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10185409/1/Olivo_oe-32-4-4839.pdf