eprintid: 10185274
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/18/52/74
datestamp: 2024-02-29 08:16:21
lastmod: 2024-02-29 08:16:21
status_changed: 2024-02-29 08:16:21
type: thesis
metadata_visibility: show
sword_depositor: 699
creators_name: Morahan, Ashley James
title: Technical Evaluation of the World's First Simultaneous Clinical SPECT-MRI Imaging System
ispublished: unpub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
note: Copyright © The Author 2024.  Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/).  Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms.  Access may initially be restricted at the author’s request.
abstract: This thesis outlines the analysis and evolution of a SPECT insert system designed
for simultaneous use within a clinical MRI. The INSERT (INtegrated SPECT/MRI
for Enhanced stratification of brain tumours in Radio-chemoTherapy) is the world’s
first clinical SPECT-MRI brain imaging system based on scintillation detectors with
a SiPM readout. This work demonstrates its use as a stand-alone SPECT scanner
and a simultaneous SPECT-MRI. The use of a clinical SPECT-MRI is carried out
here for the first time. The development of this novel technology is outlined, and its
applications were investigated to establish the first-in-man study. The stand-alone
SPECT scanner is evaluated, and its limitations are addressed through phantom
studies in which techniques such as statistical image reconstruction, Monte Carlo
simulations, and deep learning are deployed to solve issues with the SPECT design
and performance. The system is used within a clinical environment and compared to
established SPECT scanners to evaluate its feasibility as a clinical scanner. Finally,
the INSERT is installed within an MRI and evaluated as a simultaneous clinical system. Hardware upgrades and development of specialised MRI imaging sequences
allowed both systems to operate in unison. This body of work establishes the possibility of a simultaneous clinical SPECT-MRI. It looks to develop the technology
further through patient trials and continued improvements of the clinical system.
date: 2024-01-28
date_type: published
oa_status: green
full_text_type: other
thesis_class: doctoral_open
thesis_award: Ph.D
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2139100
lyricists_name: Morahan, Ashley
lyricists_id: AMORA55
actors_name: Morahan, Ashley
actors_name: Allington-Smith, Dominic
actors_id: AMORA55
actors_id: DAALL44
actors_role: owner
actors_role: impersonator
full_text_status: public
pages: 217
institution: UCL (University College London)
department: Medical Physics & Biomedical Engineering
thesis_type: Doctoral
citation:        Morahan, Ashley James;      (2024)    Technical Evaluation of the World's First Simultaneous Clinical SPECT-MRI Imaging System.                   Doctoral thesis  (Ph.D), UCL (University College London).     Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10185274/1/UCL_Thesis%202.pdf