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<https://discovery.ucl.ac.uk/id/eprint/10185274> <http://purl.org/ontology/bibo/abstract> "This thesis outlines the analysis and evolution of a SPECT insert system designed\r\nfor simultaneous use within a clinical MRI. The INSERT (INtegrated SPECT/MRI\r\nfor Enhanced stratification of brain tumours in Radio-chemoTherapy) is the world’s\r\nfirst clinical SPECT-MRI brain imaging system based on scintillation detectors with\r\na SiPM readout. This work demonstrates its use as a stand-alone SPECT scanner\r\nand a simultaneous SPECT-MRI. The use of a clinical SPECT-MRI is carried out\r\nhere for the first time. The development of this novel technology is outlined, and its\r\napplications were investigated to establish the first-in-man study. The stand-alone\r\nSPECT scanner is evaluated, and its limitations are addressed through phantom\r\nstudies in which techniques such as statistical image reconstruction, Monte Carlo\r\nsimulations, and deep learning are deployed to solve issues with the SPECT design\r\nand performance. The system is used within a clinical environment and compared to\r\nestablished SPECT scanners to evaluate its feasibility as a clinical scanner. Finally,\r\nthe INSERT is installed within an MRI and evaluated as a simultaneous clinical system. Hardware upgrades and development of specialised MRI imaging sequences\r\nallowed both systems to operate in unison. This body of work establishes the possibility of a simultaneous clinical SPECT-MRI. It looks to develop the technology\r\nfurther through patient trials and continued improvements of the clinical system."^^<http://www.w3.org/2001/XMLSchema#string> .
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