<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10184237> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/title> "Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/abstract> "Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/date> "2023-12-14" .
<https://discovery.ucl.ac.uk/id/document/1682784> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/volume> "14" .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/issue> "1" .
<https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> <http://xmlns.com/foaf/0.1/name> "Springer Science and Business Media LLC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10184237#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10184237#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> .
<https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> <http://xmlns.com/foaf/0.1/givenName> "Zhengming"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-072fbc909a812b556137ac2a3f708bf0> <http://xmlns.com/foaf/0.1/name> "Zhengming Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> <http://xmlns.com/foaf/0.1/givenName> "Gautam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> <http://xmlns.com/foaf/0.1/familyName> "Mehta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3c936918da0ec83f7d26ba032bb6dd2f> <http://xmlns.com/foaf/0.1/name> "Gautam Mehta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> <http://xmlns.com/foaf/0.1/givenName> "Steven"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> <http://xmlns.com/foaf/0.1/familyName> "Bell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cde9af09ee63a1f1e0ff816a73598c7e> <http://xmlns.com/foaf/0.1/name> "Steven Bell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> <http://xmlns.com/foaf/0.1/givenName> "Linda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> <http://xmlns.com/foaf/0.1/familyName> "Ng Fat"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-344cf1771716c8171e0f5911cd834fd2> <http://xmlns.com/foaf/0.1/name> "Linda Ng Fat"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> <http://xmlns.com/foaf/0.1/givenName> "Iona Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> <http://xmlns.com/foaf/0.1/familyName> "Millwood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28863a6206d032d14e948f1fc0dbb1b9> <http://xmlns.com/foaf/0.1/name> "Iona Y Millwood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> <http://xmlns.com/foaf/0.1/givenName> "Annie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> <http://xmlns.com/foaf/0.1/familyName> "Britton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04022533f06dcb8ec34694c5e55cb135> <http://xmlns.com/foaf/0.1/name> "Annie Britton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> <http://xmlns.com/foaf/0.1/givenName> "Pek Kei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> <http://xmlns.com/foaf/0.1/familyName> "Im"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ce2df789818bc6bd76d9110bff66d4fe> <http://xmlns.com/foaf/0.1/name> "Pek Kei Im"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> <http://xmlns.com/foaf/0.1/givenName> "Chengyi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> <http://xmlns.com/foaf/0.1/familyName> "Ding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e14c173a7a2ac982530318f951aedee8> <http://xmlns.com/foaf/0.1/name> "Chengyi Ding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> <http://xmlns.com/foaf/0.1/givenName> "Liming"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e862f79defb2d0e098ae76ddeddfdcb9> <http://xmlns.com/foaf/0.1/name> "Liming Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> <http://xmlns.com/foaf/0.1/givenName> "Kuang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> <http://xmlns.com/foaf/0.1/familyName> "Lin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-95a909b94ff7d26ce598e2730a7c3e43> <http://xmlns.com/foaf/0.1/name> "Kuang Lin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> <http://xmlns.com/foaf/0.1/givenName> "Anya"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> <http://xmlns.com/foaf/0.1/familyName> "Topiwala"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c9a7ff9419d2633d8d826db16c561a> <http://xmlns.com/foaf/0.1/name> "Anya Topiwala"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1682784> .
<https://discovery.ucl.ac.uk/id/document/1682784> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1682784> <http://www.w3.org/2000/01/rdf-schema#label> "Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1682784> .
<https://discovery.ucl.ac.uk/id/eprint/10184237> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1682784> .
<https://discovery.ucl.ac.uk/id/document/1682784> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10184237/1/s41467-023-43064-x.pdf> .
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