eprintid: 10183384 rev_number: 10 eprint_status: archive userid: 699 dir: disk0/10/18/33/84 datestamp: 2023-12-11 17:05:08 lastmod: 2024-11-11 07:10:08 status_changed: 2023-12-11 17:05:08 type: article metadata_visibility: show sword_depositor: 699 creators_name: Joshi, Akshat creators_name: Choudhury, Saswat creators_name: Asthana, Sonal creators_name: Homer-Vanniasinkam, Shervanthi creators_name: Nambiar, Uma creators_name: Chatterjee, Kaushik title: Emerging 4D fabrication of next-generation nerve guiding conduits: a critical perspective ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F45 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: The latest advancements in the field of manufacturing for biomedicine, digital health, targeted therapy, and personalized medicine have fuelled the fabrication of smart medical devices. Four-dimensional (4D) fabrication strategies, which combine the manufacturing of three-dimensional (3D) parts with smart materials and/or design, have proved beneficial in creating customized and self-fitting structures that change their properties on demand with time. These frontier techniques that yield dynamic implants can indeed alleviate various drawbacks of current clinical practices, such as the use of sutures and complex microsurgeries and associated inflammation, among others. Among various clinical applications, 4D fabrication has lately made remarkable progress in the development of next-generation nerve-guiding conduits for treating peripheral nerve injuries (PNIs) by improving the end-to-end co-aptation of transected nerve endings. The current perspective highlights the relevance of 4D fabrication in developing state-of-the-art technologies for the treatment of PNIs. Various 4D fabrication/bio-fabrication techniques for PNI treatment are summarized while identifying the challenges and opportunities for the future. Such advancements hold immense promise for improving the quality of life of patients suffering from nerve damage and the potential for extending the treatment of many other disorders. Although the techniques are being described for PNIs, they will lend themselves suitably to certain cases of cranial nerve injuries as well. date: 2023-11-10 date_type: published publisher: RSC official_url: https://doi.org/10.1039/D3BM01299A oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2110956 doi: 10.1039/d3bm01299a medium: Print-Electronic lyricists_name: Homer-Vanniasinkam, Shervanthi lyricists_id: SHOME87 actors_name: Homer-Vanniasinkam, Shervanthi actors_id: SHOME87 actors_role: owner funding_acknowledgements: IPA/2020/000025 [Science and Engineering Research Board]; [Indian Institute of Science] full_text_status: public publication: Biomaterials Science volume: 11 number: 24 pagerange: 7703-7708 event_location: England citation: Joshi, Akshat; Choudhury, Saswat; Asthana, Sonal; Homer-Vanniasinkam, Shervanthi; Nambiar, Uma; Chatterjee, Kaushik; (2023) Emerging 4D fabrication of next-generation nerve guiding conduits: a critical perspective. Biomaterials Science , 11 (24) pp. 7703-7708. 10.1039/d3bm01299a <https://doi.org/10.1039/d3bm01299a>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10183384/2/Magrinelli_Neuropsychiatric%20Presentation%20of%20Anti-DPPX%20Progressive%20Encephalomyelitis%20with%20Rigidity%20and%20Myoclonus_AAM.pdf