<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10182228> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/title> "Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/abstract> "Few studies suggest possible links between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and Alzheimer’s disease but they have been limited by small sample sizes, diagnostic and recall bias. We used two-sample Mendelian randomization (MR) to estimate the bidirectional causal association between genetic liability to ADHD and ASD on Alzheimer’s disease. In addition, we estimated the causal effects independently of educational attainment and IQ, through multivariable Mendelian randomization (MVMR). We employed genetic variants associated with ADHD (20,183 cases/35,191 controls), ASD (18,381 cases/27,969 controls), Alzheimer’s disease (71,880 cases/383,378 controls), educational attainment (n = 766,345) and IQ (n = 269,867) using the largest GWAS of European ancestry. There was limited evidence to suggest a causal effect of genetic liability to ADHD (odds ratio [OR] = 1.00, 95% CI: 0.98–1.02, P = 0.39) or ASD (OR = 0.99, 95% CI: 0.97–1.01, P = 0.70) on Alzheimer’s disease. Similar causal effect estimates were identified as direct effects, independent of educational attainment (ADHD: OR = 1.00, 95% CI: 0.99–1.01, P = 0.76; ASD: OR = 0.99, 95% CI: 0.98–1.00, P = 0.28) and IQ (ADHD: OR = 1.00, 95% CI: 0.99–1.02. P = 0.29; ASD: OR = 0.99, 95% CI: 0.98–1.01, P = 0.99). Genetic liability to Alzheimer’s disease was not found to have a causal effect on risk of ADHD or ASD (ADHD: OR = 1.12, 95% CI: 0.86–1.44, P = 0.37; ASD: OR = 1.19, 95% CI: 0.94–1.51, P = 0.14). We found limited evidence to suggest a causal effect of genetic liability to ADHD or ASD on Alzheimer’s disease; and vice versa."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/date> "2022-10-01" . <https://discovery.ucl.ac.uk/id/document/1680564> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/volume> "12" . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/org/ext-11824811db0e6c06575f358a32be71a9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-11824811db0e6c06575f358a32be71a9> <http://xmlns.com/foaf/0.1/name> "SPRINGERNATURE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-11824811db0e6c06575f358a32be71a9> . <https://discovery.ucl.ac.uk/id/publication/ext-c0baf6901024b1a962282f28e7d785c6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-c0baf6901024b1a962282f28e7d785c6> <http://xmlns.com/foaf/0.1/name> "Translational Psychiatry"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-c0baf6901024b1a962282f28e7d785c6> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> . <https://discovery.ucl.ac.uk/id/eprint/10182228#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> . <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> <http://xmlns.com/foaf/0.1/givenName> "Christina"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> <http://xmlns.com/foaf/0.1/familyName> "Dardani"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-95874e180fdb2b64c156844467be9aea> <http://xmlns.com/foaf/0.1/name> "Christina Dardani"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> <http://xmlns.com/foaf/0.1/givenName> "Panagiota"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> <http://xmlns.com/foaf/0.1/familyName> "Pagoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c66900d29a3da6c31e10ffa49ee53e89> <http://xmlns.com/foaf/0.1/name> "Panagiota Pagoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> <http://xmlns.com/foaf/0.1/givenName> "Laura D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> <http://xmlns.com/foaf/0.1/familyName> "Howe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3c2ef772477f2b025a9a8dc008957830> <http://xmlns.com/foaf/0.1/name> "Laura D Howe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> <http://xmlns.com/foaf/0.1/givenName> "Evie"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> <http://xmlns.com/foaf/0.1/familyName> "Stergiakouli"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7b8736eb12a3ff82a51b7ae86c1e3f6> <http://xmlns.com/foaf/0.1/name> "Evie Stergiakouli"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> <http://xmlns.com/foaf/0.1/givenName> "Beate"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> <http://xmlns.com/foaf/0.1/familyName> "Leppert"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cfe1f7c4646ac6c534253bd3290dfd5> <http://xmlns.com/foaf/0.1/name> "Beate Leppert"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> <http://xmlns.com/foaf/0.1/givenName> "Roxanna"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> <http://xmlns.com/foaf/0.1/familyName> "Korologou-Linden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c6523e2d5152bedf3f2e80e09ad844> <http://xmlns.com/foaf/0.1/name> "Roxanna Korologou-Linden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> <http://xmlns.com/foaf/0.1/givenName> "Emma L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> <http://xmlns.com/foaf/0.1/familyName> "Anderson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4ba47a0a3b275336aca467eb6db84231> <http://xmlns.com/foaf/0.1/name> "Emma L Anderson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> <http://xmlns.com/foaf/0.1/givenName> "George Davey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> <http://xmlns.com/foaf/0.1/familyName> "Smith"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c22c29f25d8d68329d2572c004da5a5e> <http://xmlns.com/foaf/0.1/name> "George Davey Smith"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1680564> . <https://discovery.ucl.ac.uk/id/document/1680564> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1680564> <http://www.w3.org/2000/01/rdf-schema#label> "Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1680564> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1680564> . <https://discovery.ucl.ac.uk/id/document/1680564> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10182228/1/s41398-022-02150-2.pdf> . <https://discovery.ucl.ac.uk/id/document/1680564> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10182228/1/s41398-022-02150-2.pdf> . <https://discovery.ucl.ac.uk/id/eprint/10182228/1/s41398-022-02150-2.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "s41398-022-02150-2.pdf"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10182228> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1705812> . <https://discovery.ucl.ac.uk/id/document/1705812> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1705812> <http://www.w3.org/2000/01/rdf-schema#label> "Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/1705812> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1680564> . <https://discovery.ucl.ac.uk/id/document/1705812> <http://eprints.org/relation/isVolatileVersionOf> 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