eprintid: 10181850 rev_number: 6 eprint_status: archive userid: 699 dir: disk0/10/18/18/50 datestamp: 2023-11-23 10:38:58 lastmod: 2023-11-23 10:38:58 status_changed: 2023-11-23 10:38:58 type: article metadata_visibility: show sword_depositor: 699 creators_name: Doersam, Annica Franziska creators_name: Moser, Julia creators_name: Throm, Jana creators_name: Weiss, Magdalene creators_name: Zipfel, Stephan creators_name: Micali, Nadia creators_name: Preissl, Hubert creators_name: Giel, Katrin Elisabeth title: Maternal eating disorder severity is associated with increased latency of foetal auditory event-related brain responses ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G25 keywords: Social Sciences, Psychology, Clinical, Psychology, anorexia nervosa, brain, development, eating disorders, foetus, fMEG, pregnancy, EVOKED FIELDS, MAGNETOENCEPHALOGRAPHY, CHILDHOOD, ANOREXIA, CHILDREN, NERVOSA, MOTHERS, WOMEN note: © 2021 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Objective: Maternal eating disorders (EDs) are associated with adverse pregnancy and child outcomes. There is limited research investigating the influence of maternal EDs on foetal brain development. Method: Using foetal magnetoencephalography (fMEG), an auditory sequence was presented for 10 min to assess brain response latencies in foetuses of mothers with (n = 12) and without (n = 11) a history of anorexia nervosa (AN) in the third trimester of pregnancy. ED history and severity were assessed using the structured clinical expert interview eating disorder examination (EDE) and the self-report questionnaire EDE-Q. Results: Foetuses of mothers with AN showed delayed foetal brain responses to auditory stimulation compared to foetuses of control women. Self-reported ED symptom severity explained 34% of variance in foetal brain response latencies in the AN group. Conclusions: ED pathology was strongly associated with foetal brain response latencies in the third trimester with longer latencies in foetuses of women with a history of AN reporting more ED symptoms. Follow-up on the children is pivotal to investigate if fMEG outcomes are associated with later child development. date: 2022-01 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/erv.2870 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1897874 doi: 10.1002/erv.2870 medium: Print-Electronic lyricists_name: Micali, Nadia lyricists_id: NMICA41 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner funding_acknowledgements: F1292064 [Medical Faculty Tuebingen]; [Stiftung Begabtenforderung Cusanuswerk Open access funding enabled and organized by Projekt DEAL] full_text_status: public publication: European Eating Disorders Review volume: 30 number: 1 pagerange: 75-81 pages: 7 event_location: England issn: 1072-4133 citation: Doersam, Annica Franziska; Moser, Julia; Throm, Jana; Weiss, Magdalene; Zipfel, Stephan; Micali, Nadia; Preissl, Hubert; Doersam, Annica Franziska; Moser, Julia; Throm, Jana; Weiss, Magdalene; Zipfel, Stephan; Micali, Nadia; Preissl, Hubert; Giel, Katrin Elisabeth; - view fewer <#> (2022) Maternal eating disorder severity is associated with increased latency of foetal auditory event-related brain responses. European Eating Disorders Review , 30 (1) pp. 75-81. 10.1002/erv.2870 <https://doi.org/10.1002/erv.2870>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10181850/1/Maternal%20eating%20disorder%20severity.pdf