eprintid: 10180542 rev_number: 13 eprint_status: archive userid: 699 dir: disk0/10/18/05/42 datestamp: 2024-01-19 15:04:50 lastmod: 2024-01-19 15:04:50 status_changed: 2024-01-19 15:04:50 type: book_section metadata_visibility: show sword_depositor: 699 creators_name: Adams, Rick A title: Cortical Disinhibition, Attractor Dynamics, and Belief Updating in Schizophrenia ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: FH4 keywords: Schizophrenia; Psychosis; Computational; Beads task; Excitation-inhibition balance; Bayesian note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Genetic and pharmacological evidence implicates N-methyl-D-aspartate receptor (NMDAR) dysfunction in the pathophysiology of schizophrenia. Dysfunction of this key receptor – if localised to inhibitory interneurons – could cause a net disinhibition of cortex and increase in ‘noise’. These effects can be computationally modelled in a variety of ways: by reducing the precision in Bayesian models of behaviour, by estimating neuronal excitability changes in schizophrenia from evoked responses, or – as described in detail here – by modelling abnormal belief updating in a probabilistic inference task. Features of belief updating in schizophrenia include greater updating to unexpected evidence, lower updating to consistent evidence, and greater stochasticity in responding. All of these features can be explained by a loss of stability of ‘attractor states’ in cortex and the representations they encode. Indeed, a hierarchical Bayesian model of belief updating indicates that subjects with schizophrenia have a consistently increased ‘belief instability’ parameter. This instability could be a direct result of cortical disinhibition: this hypothesis should be explored in future studies. date: 2019-10-12 date_type: published publisher: Springer official_url: https://doi.org/10.1007/978-3-030-18830-6_8 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1776261 doi: 10.1007/978-3-030-18830-6_8 isbn_13: 978-3-030-18829-0 lyricists_name: Adams, Richard lyricists_id: RAADA06 actors_name: Adams, Richard actors_id: RAADA06 actors_role: owner full_text_status: public series: Springer Series in Cognitive and Neural Systems volume: 13 place_of_pub: Cham, Switzerland pagerange: 81-89 book_title: Multiscale Models of Brain Disorders editors_name: Cutsuridis, Vassilis citation: Adams, Rick A; (2019) Cortical Disinhibition, Attractor Dynamics, and Belief Updating in Schizophrenia. In: Cutsuridis, Vassilis, (ed.) Multiscale Models of Brain Disorders. (pp. 81-89). Springer: Cham, Switzerland. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10180542/1/Figures.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10180542/9/Adams_Adams%20chapter%20final.pdf