eprintid: 10180542
rev_number: 13
eprint_status: archive
userid: 699
dir: disk0/10/18/05/42
datestamp: 2024-01-19 15:04:50
lastmod: 2024-01-19 15:04:50
status_changed: 2024-01-19 15:04:50
type: book_section
metadata_visibility: show
sword_depositor: 699
creators_name: Adams, Rick A
title: Cortical Disinhibition, Attractor Dynamics, and Belief Updating in Schizophrenia
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: FH4
keywords: Schizophrenia; Psychosis; Computational; Beads task; 
Excitation-inhibition balance; 
Bayesian
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Genetic and pharmacological evidence implicates N-methyl-D-aspartate receptor (NMDAR) dysfunction in the pathophysiology of schizophrenia. Dysfunction of this key receptor – if localised to inhibitory interneurons – could cause a net disinhibition of cortex and increase in ‘noise’. These effects can be computationally modelled in a variety of ways: by reducing the precision in Bayesian models of behaviour, by estimating neuronal excitability changes in schizophrenia from evoked responses, or – as described in detail here – by modelling abnormal belief updating in a probabilistic inference task. Features of belief updating in schizophrenia include greater updating to unexpected evidence, lower updating to consistent evidence, and greater stochasticity in responding. All of these features can be explained by a loss of stability of ‘attractor states’ in cortex and the representations they encode. Indeed, a hierarchical Bayesian model of belief updating indicates that subjects with schizophrenia have a consistently increased ‘belief instability’ parameter. This instability could be a direct result of cortical disinhibition: this hypothesis should be explored in future studies.
date: 2019-10-12
date_type: published
publisher: Springer
official_url: https://doi.org/10.1007/978-3-030-18830-6_8
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1776261
doi: 10.1007/978-3-030-18830-6_8
isbn_13: 978-3-030-18829-0
lyricists_name: Adams, Richard
lyricists_id: RAADA06
actors_name: Adams, Richard
actors_id: RAADA06
actors_role: owner
full_text_status: public
series: Springer Series in Cognitive and Neural Systems
volume: 13
place_of_pub: Cham, Switzerland
pagerange: 81-89
book_title: Multiscale Models of Brain Disorders
editors_name: Cutsuridis, Vassilis
citation:        Adams, Rick A;      (2019)    Cortical Disinhibition, Attractor Dynamics, and Belief Updating in Schizophrenia.                    In: Cutsuridis, Vassilis, (ed.) Multiscale Models of Brain Disorders. (pp. 81-89).   Springer: Cham, Switzerland.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10180542/1/Figures.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10180542/9/Adams_Adams%20chapter%20final.pdf