eprintid: 10180434
rev_number: 11
eprint_status: archive
userid: 699
dir: disk0/10/18/04/34
datestamp: 2023-11-06 13:13:30
lastmod: 2024-10-04 06:10:05
status_changed: 2023-11-06 13:13:30
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Pates, Katharine M
creators_name: Periselneris, Jimstan N
creators_name: Brown, Jeremy S
title: Opportunistic bacterial, viral and fungal infections of the lung
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: K71
keywords: Aspergillus; Cryptococcus; fungi; immunocompromised host; 
Nocardia; opportunistic infections; pneumonia; viruses
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Respiratory opportunistic infections are a major cause of morbidity and mortality in severely immunocompromised patients, such as those treated with biological therapies, chemotherapy and solid organ or stem cell transplants, and those with haematological malignancy, aplastic anaemia or HIV infection. The type and degree of immune defect dictates the profile of potential opportunistic pathogens; T-cell-mediated defects increase the risk of viral (cytomegalovirus, respiratory viruses) and Pneumocystis jirovecii infections, whereas neutrophil defects are associated with bacterial pneumonia and invasive aspergillosis. However, patients often have combinations of immune defects, and a wide range of other opportunistic infections can cause pneumonia. Importantly, conventional non-opportunistic pathogens are also frequently encountered in immunocompromised hosts and should not be overlooked. The radiological pattern of disease (best assessed by computed tomography) and speed of onset help identify the likely pathogen(s); this can then be supported by targeted investigation including early use of bronchoscopy in selected patients. Rapid and expert clinical assessment can help identify the most likely pathogens, allowing timely appropriate therapy.
date: 2023-11
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.mpmed.2023.08.002
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2097984
doi: 10.1016/j.mpmed.2023.08.002
lyricists_name: Brown, Jeremy
lyricists_id: JBROW91
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Medicine
volume: 51
number: 11
pagerange: 777-783
issn: 1357-3039
citation:        Pates, Katharine M;    Periselneris, Jimstan N;    Brown, Jeremy S;      (2023)    Opportunistic bacterial, viral and fungal infections of the lung.                   Medicine , 51  (11)   pp. 777-783.    10.1016/j.mpmed.2023.08.002 <https://doi.org/10.1016/j.mpmed.2023.08.002>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10180434/1/Brown_Opportunistic%20bacterial%2C%20viral%20and%20fungal%20infections%20of%20the%20lung.pdf