<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10180232> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/title> "Human wild-type and D76N β_{2}-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/abstract> "β2-microglobulin (β2-m) is a plasma protein derived from physiological shedding of the class I major histocompatibility complex (MHCI), causing human systemic amyloidosis either due to persistently high concentrations of the wild-type (WT) protein in hemodialyzed patients, or in presence of mutations, such as D76N β2-m, which favor protein deposition in the adulthood, despite normal plasma levels. Here we describe a new transgenic Caenorhabditis elegans (C. elegans) strain expressing human WT β2-m at high concentrations, mimicking the condition that underlies dialysis-related amyloidosis (DRA) and we compare it to a previously established strain expressing the highly amyloidogenic D76N β2-m at lower concentrations. Both strains exhibit behavioral defects, the severity of which correlates with β2-m levels rather than with the presence of mutations, being more pronounced in WT β2-m worms. β2-m expression also has a deep impact on the nematodes' proteomic and metabolic profiles. Most significantly affected processes include protein degradation and stress response, amino acids metabolism, and bioenergetics. Molecular alterations are more pronounced in worms expressing WT β2-m at high concentration compared to D76N β2-m worms. Altogether, these data show that β2-m is a proteotoxic protein in vivo also in its wild-type form, and that concentration plays a key role in modulating pathogenicity. Our transgenic nematodes recapitulate the distinctive features subtending DRA compared to hereditary β2-m amyloidosis (high levels of non-mutated β2-m vs. normal levels of variant β2-m) and provide important clues on the molecular bases of these human diseases."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/date> "2023-11" .
<https://discovery.ucl.ac.uk/id/document/1670310> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/volume> "5" .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/issue> "11" .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://xmlns.com/foaf/0.1/name> "Wiley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> .
<https://discovery.ucl.ac.uk/id/publication/ext-058f4d5889c488e80691697b6c9d816f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-058f4d5889c488e80691697b6c9d816f> <http://xmlns.com/foaf/0.1/name> "FASEB BioAdvances"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-058f4d5889c488e80691697b6c9d816f> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a8932199bceb87f76b694d01154d47bb> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-a8932199bceb87f76b694d01154d47bb> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32121efeddae859c507757e8909fc9c4> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-32121efeddae859c507757e8909fc9c4> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f09f4da009f83739557b55a1b1e0231> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-3f09f4da009f83739557b55a1b1e0231> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a4166feaae7c8f9ed94952b0ab66bbcc> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-a4166feaae7c8f9ed94952b0ab66bbcc> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ac996e33aca93510dc94861d16770738> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-ac996e33aca93510dc94861d16770738> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> .
<https://discovery.ucl.ac.uk/id/eprint/10180232> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10180232#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10180232#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> <http://xmlns.com/foaf/0.1/familyName> "Verona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a68d8107ced64f8f0e97ed522436e3> <http://xmlns.com/foaf/0.1/name> "G Verona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> <http://xmlns.com/foaf/0.1/familyName> "Mondani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ea412d10425ae29b948a35c1210ca865> <http://xmlns.com/foaf/0.1/name> "V Mondani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> <http://xmlns.com/foaf/0.1/familyName> "Faravelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00a9abbf3baff3f51d5d0a1b01d8f796> <http://xmlns.com/foaf/0.1/name> "G Faravelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> <http://xmlns.com/foaf/0.1/familyName> "Marchese"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f2a46cd57c4d6bd5e049a3fe2a40d333> <http://xmlns.com/foaf/0.1/name> "L Marchese"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> <http://xmlns.com/foaf/0.1/familyName> "Bellotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6097e352b19e5aca7bd7f5cdaa083c4a> <http://xmlns.com/foaf/0.1/name> "V Bellotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> <http://xmlns.com/foaf/0.1/givenName> "PP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> <http://xmlns.com/foaf/0.1/familyName> "Mangione"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ca73c6b05824f0ef7a10cce69b8f6f12> <http://xmlns.com/foaf/0.1/name> "PP Mangione"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> <http://xmlns.com/foaf/0.1/familyName> "Lavatelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-50342e2476f9004038bd3632fa844622> <http://xmlns.com/foaf/0.1/name> "F Lavatelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> <http://xmlns.com/foaf/0.1/familyName> "Caterino"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18ae4769120c5130aac295fe95145601> <http://xmlns.com/foaf/0.1/name> "M Caterino"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> <http://xmlns.com/foaf/0.1/givenName> "MC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> <http://xmlns.com/foaf/0.1/familyName> "Mimmi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb6840767dcc62decf733c91cc545f74> <http://xmlns.com/foaf/0.1/name> "MC Mimmi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> <http://xmlns.com/foaf/0.1/familyName> "Giorgetti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fae885602831c6766876df508179594a> <http://xmlns.com/foaf/0.1/name> "S Giorgetti"^^<http://www.w3.org/2001/XMLSchema#string> .
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