eprintid: 10179566
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/17/95/66
datestamp: 2023-10-25 09:15:39
lastmod: 2023-10-25 09:15:39
status_changed: 2023-10-25 09:15:39
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Monosov, Ilya E
creators_name: Ogasawara, Takaya
creators_name: Haber, Suzanne N
creators_name: Heimel, J Alexander
creators_name: Ahmadlou, Mehran
title: The zona incerta in control of novelty seeking and investigation across species
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D75
keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, DEEP BRAIN-STIMULATION, FRONTAL EYE FIELD, PRIMATE SPINOTHALAMIC PATHWAYS, BASAL GANGLIA CIRCUITS, PERIRHINAL CORTEX, SUPERIOR COLLICULUS, SUBCORTICAL CONNECTIONS, EFFERENT CONNECTIONS, MULTIPLE TIMESCALES, ENTORHINAL CORTICES
note: © 2022 The Author(s). Published by Elsevier Ltd. This is an
open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: Many organisms rely on a capacity to rapidly replicate, disperse, and evolve when faced with uncertainty and novelty. But mammals do not evolve and replicate quickly. They rely on a sophisticated nervous system to generate predictions and select responses when confronted with these challenges. An important component of their behavioral repertoire is the adaptive context-dependent seeking or avoiding of perceptually novel objects, even when their values have not yet been learned. Here, we outline recent cross-species breakthroughs that shed light on how the zona incerta (ZI), a relatively evolutionarily conserved brain area, supports novelty-seeking and novelty-related investigations. We then conjecture how the architecture of the ZI's anatomical connectivity – the wide-ranging top-down cortical inputs to the ZI, and its specifically strong outputs to both the brainstem action controllers and to brain areas involved in action value learning – place the ZI in a unique role at the intersection of cognitive control and learning.
date: 2022-11-15
date_type: published
publisher: CURRENT BIOLOGY LTD
official_url: https://doi.org/10.1016/j.conb.2022.102650
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1992737
doi: 10.1016/j.conb.2022.102650
medium: Print-Electronic
pii: S0959-4388(22)00144-1
lyricists_name: Ahmadlou, Mehran
lyricists_id: MAHMF70
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: R01MH128344 [National Institute of Mental Health]; R01MH110594 [National Institute of Mental Health]; R01MH116937 [National Institute of Mental Health]; [McKnight Foundation]; MH10643 [Neuro-circuitry of OCD]; M20.114 [NWO]; [Dr. J.L. Dobberke Foundation]
full_text_status: public
publication: Current Opinion in Neurobiology
volume: 77
article_number: 102650
pages: 15
event_location: England
issn: 0959-4388
citation:        Monosov, Ilya E;    Ogasawara, Takaya;    Haber, Suzanne N;    Heimel, J Alexander;    Ahmadlou, Mehran;      (2022)    The zona incerta in control of novelty seeking and investigation across species.                   Current Opinion in Neurobiology , 77     , Article 102650.  10.1016/j.conb.2022.102650 <https://doi.org/10.1016/j.conb.2022.102650>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10179566/1/1-s2.0-S0959438822001441-main.pdf