eprintid: 10179566 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/17/95/66 datestamp: 2023-10-25 09:15:39 lastmod: 2023-10-25 09:15:39 status_changed: 2023-10-25 09:15:39 type: article metadata_visibility: show sword_depositor: 699 creators_name: Monosov, Ilya E creators_name: Ogasawara, Takaya creators_name: Haber, Suzanne N creators_name: Heimel, J Alexander creators_name: Ahmadlou, Mehran title: The zona incerta in control of novelty seeking and investigation across species ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D75 keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, DEEP BRAIN-STIMULATION, FRONTAL EYE FIELD, PRIMATE SPINOTHALAMIC PATHWAYS, BASAL GANGLIA CIRCUITS, PERIRHINAL CORTEX, SUPERIOR COLLICULUS, SUBCORTICAL CONNECTIONS, EFFERENT CONNECTIONS, MULTIPLE TIMESCALES, ENTORHINAL CORTICES note: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). abstract: Many organisms rely on a capacity to rapidly replicate, disperse, and evolve when faced with uncertainty and novelty. But mammals do not evolve and replicate quickly. They rely on a sophisticated nervous system to generate predictions and select responses when confronted with these challenges. An important component of their behavioral repertoire is the adaptive context-dependent seeking or avoiding of perceptually novel objects, even when their values have not yet been learned. Here, we outline recent cross-species breakthroughs that shed light on how the zona incerta (ZI), a relatively evolutionarily conserved brain area, supports novelty-seeking and novelty-related investigations. We then conjecture how the architecture of the ZI's anatomical connectivity – the wide-ranging top-down cortical inputs to the ZI, and its specifically strong outputs to both the brainstem action controllers and to brain areas involved in action value learning – place the ZI in a unique role at the intersection of cognitive control and learning. date: 2022-11-15 date_type: published publisher: CURRENT BIOLOGY LTD official_url: https://doi.org/10.1016/j.conb.2022.102650 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1992737 doi: 10.1016/j.conb.2022.102650 medium: Print-Electronic pii: S0959-4388(22)00144-1 lyricists_name: Ahmadlou, Mehran lyricists_id: MAHMF70 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner funding_acknowledgements: R01MH128344 [National Institute of Mental Health]; R01MH110594 [National Institute of Mental Health]; R01MH116937 [National Institute of Mental Health]; [McKnight Foundation]; MH10643 [Neuro-circuitry of OCD]; M20.114 [NWO]; [Dr. J.L. Dobberke Foundation] full_text_status: public publication: Current Opinion in Neurobiology volume: 77 article_number: 102650 pages: 15 event_location: England issn: 0959-4388 citation: Monosov, Ilya E; Ogasawara, Takaya; Haber, Suzanne N; Heimel, J Alexander; Ahmadlou, Mehran; (2022) The zona incerta in control of novelty seeking and investigation across species. Current Opinion in Neurobiology , 77 , Article 102650. 10.1016/j.conb.2022.102650 <https://doi.org/10.1016/j.conb.2022.102650>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10179566/1/1-s2.0-S0959438822001441-main.pdf