TY - JOUR TI - The zona incerta in control of novelty seeking and investigation across species SN - 0959-4388 Y1 - 2022/11/15/ AV - public N2 - Many organisms rely on a capacity to rapidly replicate, disperse, and evolve when faced with uncertainty and novelty. But mammals do not evolve and replicate quickly. They rely on a sophisticated nervous system to generate predictions and select responses when confronted with these challenges. An important component of their behavioral repertoire is the adaptive context-dependent seeking or avoiding of perceptually novel objects, even when their values have not yet been learned. Here, we outline recent cross-species breakthroughs that shed light on how the zona incerta (ZI), a relatively evolutionarily conserved brain area, supports novelty-seeking and novelty-related investigations. We then conjecture how the architecture of the ZI's anatomical connectivity ? the wide-ranging top-down cortical inputs to the ZI, and its specifically strong outputs to both the brainstem action controllers and to brain areas involved in action value learning ? place the ZI in a unique role at the intersection of cognitive control and learning. ID - discovery10179566 UR - https://doi.org/10.1016/j.conb.2022.102650 EP - 15 N1 - © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). VL - 77 KW - Science & Technology KW - Life Sciences & Biomedicine KW - Neurosciences KW - Neurosciences & Neurology KW - DEEP BRAIN-STIMULATION KW - FRONTAL EYE FIELD KW - PRIMATE SPINOTHALAMIC PATHWAYS KW - BASAL GANGLIA CIRCUITS KW - PERIRHINAL CORTEX KW - SUPERIOR COLLICULUS KW - SUBCORTICAL CONNECTIONS KW - EFFERENT CONNECTIONS KW - MULTIPLE TIMESCALES KW - ENTORHINAL CORTICES PB - CURRENT BIOLOGY LTD A1 - Monosov, Ilya E A1 - Ogasawara, Takaya A1 - Haber, Suzanne N A1 - Heimel, J Alexander A1 - Ahmadlou, Mehran JF - Current Opinion in Neurobiology ER -