TY  - JOUR
TI  - The zona incerta in control of novelty seeking and investigation across species
SN  - 0959-4388
Y1  - 2022/11/15/
AV  - public
N2  - Many organisms rely on a capacity to rapidly replicate, disperse, and evolve when faced with uncertainty and novelty. But mammals do not evolve and replicate quickly. They rely on a sophisticated nervous system to generate predictions and select responses when confronted with these challenges. An important component of their behavioral repertoire is the adaptive context-dependent seeking or avoiding of perceptually novel objects, even when their values have not yet been learned. Here, we outline recent cross-species breakthroughs that shed light on how the zona incerta (ZI), a relatively evolutionarily conserved brain area, supports novelty-seeking and novelty-related investigations. We then conjecture how the architecture of the ZI's anatomical connectivity ? the wide-ranging top-down cortical inputs to the ZI, and its specifically strong outputs to both the brainstem action controllers and to brain areas involved in action value learning ? place the ZI in a unique role at the intersection of cognitive control and learning.
ID  - discovery10179566
UR  - https://doi.org/10.1016/j.conb.2022.102650
EP  - 15
N1  - © 2022 The Author(s). Published by Elsevier Ltd. This is an
open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 77
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  DEEP BRAIN-STIMULATION
KW  -  FRONTAL EYE FIELD
KW  -  PRIMATE SPINOTHALAMIC PATHWAYS
KW  -  BASAL GANGLIA CIRCUITS
KW  -  PERIRHINAL CORTEX
KW  -  SUPERIOR COLLICULUS
KW  -  SUBCORTICAL CONNECTIONS
KW  -  EFFERENT CONNECTIONS
KW  -  MULTIPLE TIMESCALES
KW  -  ENTORHINAL CORTICES
PB  - CURRENT BIOLOGY LTD
A1  - Monosov, Ilya E
A1  - Ogasawara, Takaya
A1  - Haber, Suzanne N
A1  - Heimel, J Alexander
A1  - Ahmadlou, Mehran
JF  - Current Opinion in Neurobiology
ER  -