?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Classification+of+brain+injury+severity+using+a+hybrid+broadband+NIRS+and+DCS+instrument+with+a+machine+learning+approach&rft.creator=Bili%2C+Danai&rft.creator=Lange%2C+Fr%C3%A9d%C3%A9ric&rft.creator=Jones%2C+Kelly+H&rft.creator=Parfentyeva%2C+Veronika&rft.creator=Durduran%2C+Turgut&rft.creator=Robertson%2C+Nikki&rft.creator=Mitra%2C+Subhabrata&rft.creator=Tachtsidis%2C+Ilias&rft.description=Optical+biomarkers+of+neonatal+hypoxic+ischemic+(HI)+brain+injury+can+offer+the+advantage+of+continuous%2C+cot-side+assessment+of+the+degree+of+injury%3B+research+thus+far+has+focused+on+examining+different+optical+measured+brain+physiological+signals+and+feature+combinations+to+achieve+this.+To+maximize+the+breadth+of+physiological+characteristics+being+taken+into+consideration%2C+a+multimodal+optical+platform+has+been+developed%2C+allowing+unique+physiological+insights+into+brain+injury.+In+this+paper+we+present+an+assessment+of+severity+of+injury+using+a+state-of-the-art+hybrid+broadband+Near+Infrared+Spectrometer+(bNIRS)+and+Diffusion+Correlation+Spectrometer+(DCS)+instrument+called+FLORENCE+with+a+machine+learning+pipeline.+We+demonstrate+in+the+preclinical+neonatal+model+(the+newborn+piglet)+that+our+approach+can+identify+different+HI+insult+severity+(controls%2C+mild%2C+severe).+We+show+that+a+machine+learning+pipeline+based+on+k-means+clustering+can+be+used+to+differentiate+between+the+controls+and+the+HI+piglets+with+an+accuracy+of+78%25%2C+the+mild+severity+insult+piglets+from+the+severe+insult+piglets+with+an+accuracy+of+90%25+and+can+also+differentiate+the+3+piglet+groups+with+an+accuracy+of+80%25.+So%2C+this+analytics+pipeline+demonstrates+how+optical+data+from+multiple+instruments+can+be+processed+towards+markers+of+brain+health.&rft.publisher=SPIE&rft.contributor=Contini%2C+Davide&rft.contributor=Hoshi%2C+Yoko&rft.contributor=O'Sullivan%2C+Thomas+D&rft.date=2023-08-09&rft.type=Proceedings+paper&rft.language=eng&rft.source=+++++In%3A+Contini%2C+Davide+and+Hoshi%2C+Yoko+and+O'Sullivan%2C+Thomas+D%2C+(eds.)+Proceedings+Volume+12628%2C+Diffuse+Optical+Spectroscopy+and+Imaging+IX.++(pp.+126280D).++SPIE%3A+Munich%2C+Germany.+(2023)+++++&rft.format=application%2Fpdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10179358%2F1%2F126280D.pdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10179358%2F&rft.rights=open