eprintid: 10179142
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/17/91/42
datestamp: 2023-10-19 09:33:42
lastmod: 2023-10-19 09:33:42
status_changed: 2023-10-19 09:33:42
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Shimizu, Takahiro
creators_name: Nayar, Stuart G
creators_name: Swire, Matthew
creators_name: Jiang, Yi
creators_name: Grist, Matthew
creators_name: Kaller, Malte
creators_name: Sampaio Baptista, Cassandra
creators_name: Bannerman, David M
creators_name: Johansen-Berg, Heidi
creators_name: Ogasawara, Katsutoshi
creators_name: Tohyama, Koujiro
creators_name: Li, Huiliang
creators_name: Richardson, William D
title: Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G95
note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
abstract: Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is also required for non-motor learning and cognition, using T-maze and radial-arm-maze tasks that tax spatial working memory. We find that maze training stimulates OLP proliferation and OL production in the medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus and hippocampal formation of adult male mice; myelin sheath formation is also stimulated in the genu. Genetic blockade of OL differentiation and neo-myelination in Myrf conditional-knockout mice strongly impairs training-induced improvements in maze performance. We find a strong positive correlation between the performance of individual wild type mice and the scale of OLP proliferation and OL generation during training, but not with the number or intensity of c-Fos+ neurons in their mPFC, underscoring the important role played by OL lineage cells in cognitive processing.
date: 2023-10-14
date_type: published
official_url: https://doi.org/10.1038/s41467-023-42293-4
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2097113
doi: 10.1038/s41467-023-42293-4
medium: Electronic
pii: 10.1038/s41467-023-42293-4
lyricists_name: Li, Huiliang
lyricists_name: Richardson, William
lyricists_name: Grist, Matthew
lyricists_name: Nayar, Stuart
lyricists_id: HLIXX97
lyricists_id: WDRIC46
lyricists_id: MGRIS74
lyricists_id: SNAYA54
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Nature Communications
volume: 14
article_number: 6499
event_location: England
issn: 2041-1723
citation:        Shimizu, Takahiro;    Nayar, Stuart G;    Swire, Matthew;    Jiang, Yi;    Grist, Matthew;    Kaller, Malte;    Sampaio Baptista, Cassandra;                         ... Richardson, William D; + view all <#>        Shimizu, Takahiro;  Nayar, Stuart G;  Swire, Matthew;  Jiang, Yi;  Grist, Matthew;  Kaller, Malte;  Sampaio Baptista, Cassandra;  Bannerman, David M;  Johansen-Berg, Heidi;  Ogasawara, Katsutoshi;  Tohyama, Koujiro;  Li, Huiliang;  Richardson, William D;   - view fewer <#>    (2023)    Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice.                   Nature Communications , 14     , Article 6499.  10.1038/s41467-023-42293-4 <https://doi.org/10.1038/s41467-023-42293-4>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10179142/1/s41467-023-42293-4.pdf