TY  - JOUR
JF  - Nature Communications
A1  - Shimizu, Takahiro
A1  - Nayar, Stuart G
A1  - Swire, Matthew
A1  - Jiang, Yi
A1  - Grist, Matthew
A1  - Kaller, Malte
A1  - Sampaio Baptista, Cassandra
A1  - Bannerman, David M
A1  - Johansen-Berg, Heidi
A1  - Ogasawara, Katsutoshi
A1  - Tohyama, Koujiro
A1  - Li, Huiliang
A1  - Richardson, William D
N2  - Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is also required for non-motor learning and cognition, using T-maze and radial-arm-maze tasks that tax spatial working memory. We find that maze training stimulates OLP proliferation and OL production in the medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus and hippocampal formation of adult male mice; myelin sheath formation is also stimulated in the genu. Genetic blockade of OL differentiation and neo-myelination in Myrf conditional-knockout mice strongly impairs training-induced improvements in maze performance. We find a strong positive correlation between the performance of individual wild type mice and the scale of OLP proliferation and OL generation during training, but not with the number or intensity of c-Fos+ neurons in their mPFC, underscoring the important role played by OL lineage cells in cognitive processing.
ID  - discovery10179142
UR  - https://doi.org/10.1038/s41467-023-42293-4
SN  - 2041-1723
N1  - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article?s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article?s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
TI  - Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice
Y1  - 2023/10/14/
AV  - public
VL  - 14
ER  -