<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10179018> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/title> "A phase 1b dose-escalation study of carfilzomib in combination with thalidomide and dexamethasone in patients with relapsed/refractory systemic immunoglobulin light chain amyloidosis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/abstract> "INTRODUCTION: Proteasome inhibitors are the backbone of AL amyloidosis treatment - bortezomib being most widely used. Carfilzomib is a proteasome inhibitor licenced to treat multiple myeloma; autonomic and peripheral neuropathy are uncommon toxicities with carfilzomib. There is limited data on the use of carfilzomib in AL amyloidosis. Here, we report the results of a phase Ib dose-escalation study of Carfilzomib-Thalidomide-Dexamethasone (KTD) in relapsed/refractory AL amyloidosis. RESULTS: The trial registered 11 patients from 6 UK centres from September 2017 to January 2019; 10 patients received at least one dose of trial treatment. 80 adverse events were reported from 10 patients in the 1st three cycles. One patient experienced dose-limiting toxicity (acute kidney injury) at a dose of 45 mg/m2, and another patient had a SAR (fever). Five patients experienced an AE ≥ grade 3. There were no haematologic, infectious, or cardiac AE ≥ grade 3. The overall haematological response rate (ORR) at the end of three cycles of treatment was 60%. CONCLUSION: Carfilzomib 45 mg/m2 weekly can be safely given with thalidomide and dexamethasone. The efficacy and tolerability profile appears comparable to other agents in relapsed AL amyloidosis. These data provide a framework for further studies of carfilzomib combinations in AL amyloidosis."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/date> "2023-05-22" .
<https://discovery.ucl.ac.uk/id/document/1661690> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/1661696> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/volume> "30" .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/org/ext-82d97d3d46da72def3ef996d0ad0810c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-82d97d3d46da72def3ef996d0ad0810c> <http://xmlns.com/foaf/0.1/name> "Informa UK Limited"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-82d97d3d46da72def3ef996d0ad0810c> .
<https://discovery.ucl.ac.uk/id/publication/ext-38e493aa7f4f3365c6ae8a73e49900f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-38e493aa7f4f3365c6ae8a73e49900f5> <http://xmlns.com/foaf/0.1/name> "Amyloid"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-38e493aa7f4f3365c6ae8a73e49900f5> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32d33f3d4a0f7f57bf5dffc299e2358e> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-32d33f3d4a0f7f57bf5dffc299e2358e> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b088e0943f3d05174d2a790ce933d4e1> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-b088e0943f3d05174d2a790ce933d4e1> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0f7f92e0d5639226cb61eec33736ff55> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-0f7f92e0d5639226cb61eec33736ff55> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e95fa036f3aaff65e4973dd67ba2658e> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-e95fa036f3aaff65e4973dd67ba2658e> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> .
<https://discovery.ucl.ac.uk/id/eprint/10179018> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10179018#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10179018#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> .
<https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> <http://xmlns.com/foaf/0.1/givenName> "Ashutosh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> <http://xmlns.com/foaf/0.1/familyName> "Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a77bca2d50c79bd9382737919f0e862a> <http://xmlns.com/foaf/0.1/name> "Ashutosh Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> <http://xmlns.com/foaf/0.1/givenName> "Shameem"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> <http://xmlns.com/foaf/0.1/familyName> "Mahmood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b18f4381e08d98c05bcfae0b17955d5> <http://xmlns.com/foaf/0.1/name> "Shameem Mahmood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> <http://xmlns.com/foaf/0.1/givenName> "Julian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> <http://xmlns.com/foaf/0.1/familyName> "Gillmore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14827963955bb015d25c9f1f641df8aa> <http://xmlns.com/foaf/0.1/name> "Julian Gillmore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> <http://xmlns.com/foaf/0.1/givenName> "Jamie B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> <http://xmlns.com/foaf/0.1/familyName> "Oughton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45791c72a1524179f423aa5853312483> <http://xmlns.com/foaf/0.1/name> "Jamie B Oughton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> <http://xmlns.com/foaf/0.1/givenName> "Helen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> <http://xmlns.com/foaf/0.1/familyName> "Lachmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b546383742510ddc77aed3e7b7a32d73> <http://xmlns.com/foaf/0.1/name> "Helen Lachmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> <http://xmlns.com/foaf/0.1/givenName> "Alexandra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> <http://xmlns.com/foaf/0.1/familyName> "Pitchford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-11d0d6b7068b19098f95fbbab38fb287> <http://xmlns.com/foaf/0.1/name> "Alexandra Pitchford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> <http://xmlns.com/foaf/0.1/givenName> "Sriram"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> <http://xmlns.com/foaf/0.1/familyName> "Ravichandran"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-229b9f8d6799b0971cd14e50c5c8d56a> <http://xmlns.com/foaf/0.1/name> "Sriram Ravichandran"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> <http://xmlns.com/foaf/0.1/givenName> "Mamta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> <http://xmlns.com/foaf/0.1/familyName> "Garg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-765a45ecb5393c06c85a78617d194d37> <http://xmlns.com/foaf/0.1/name> "Mamta Garg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> <http://xmlns.com/foaf/0.1/givenName> "Matthew"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> <http://xmlns.com/foaf/0.1/familyName> "Jenner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82eb7b7496e2753dc38d00a797addca> <http://xmlns.com/foaf/0.1/name> "Matthew Jenner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> <http://xmlns.com/foaf/0.1/givenName> "Philip"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> <http://xmlns.com/foaf/0.1/familyName> "Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a332db243afb522cffa228c50ea5579> <http://xmlns.com/foaf/0.1/name> "Philip Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b088e0943f3d05174d2a790ce933d4e1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b088e0943f3d05174d2a790ce933d4e1> <http://xmlns.com/foaf/0.1/givenName> "Bhuvan"^^<http://www.w3.org/2001/XMLSchema#string> .
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