TY - JOUR EP - 117 A1 - Pressler, Ronit M A1 - Robinson, Richard O A1 - Wilson, Goigia A A1 - Binnie, Colin D KW - AED KW - Antiepileptic drug KW - MANOVA KW - Multivariate analysis of variance KW - NCYPE KW - National Centre for Young People with Epilepsy KW - TCI KW - Transitory cognitive impairment KW - EEG KW - Electroencephalography IS - 1 TI - Treatment of interictal epileptiform discharges can improve behavior in children with behavioral problems and epilepsy Y1 - 2005/01// VL - 146 SP - 112 SN - 0022-3476 N2 - Objectives: It is generally agreed that children should be treated for epilepsy only if they have clinical seizures. The aim of this study was to examine whether suppressing interictal discharges can affect behavior in children with epilepsy.// Study design: In a double-blinded, placebo-controlled, crossover study, 61 children with well-controlled or mild epilepsy were randomly assigned to add-on therapy with either lamotrigine followed by placebo or placebo followed by lamotrigine. Ambulatory electroencephalographic recordings and behavioral scales were performed during baseline and at the end of placebo and drug phases. The primary hypothesis to be tested was that behavioral scales would improve specifically in patients with a reduction of electroencephalographic discharges during active drug treatment.// Results: Global rating of behavior significantly improved only in patients who showed a significant reduction in either frequency (P < .05) or duration of discharges (P < .05) during active treatment but not in patients with without a significant change in discharge rate. This improvement was mainly seen in patients with partial epilepsy (P < .005).// Conclusions: Our data suggest that suppressing interictal discharges can improve behavior in children with epilepsy and behavioral problems, particularly partial epilepsy. Focal discharges may be involved in the underlying mechanisms of behavioral problems in epilepsy. AV - public N1 - This version is the author-accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. ID - discovery10177149 UR - https://doi.org/10.1016/j.jpeds.2004.08.084 PB - MOSBY-ELSEVIER JF - The Journal of Pediatrics ER -