@article{discovery10177148,
       publisher = {ELSEVIER IRELAND LTD},
            note = {This version is the author-accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
           pages = {31--37},
         journal = {Clinical Neurophysiology},
           month = {January},
           title = {Early serial EEG in hypoxic ischaemic encephalopathy},
          number = {1},
          volume = {112},
            year = {2001},
          author = {Pressler, RM and Boylan, GB and Morton, M and Binnie, CD and Rennie, JM},
             url = {https://doi.org/10.1016/S1388-2457(00)00517-4},
        abstract = {Objectives: To perform early serial EEGs in infants with hypoxic ischaemic encephalopathy (HIE) and compare the findings with neurodevelopmental outcome.//

Methods: Nine full-term neonates with HIE had simultaneous video-EEG polygraphic studies within 8 h of birth. The EEG was repeated at 12-24 h intervals. All surviving infants had a neurodevelopmental assessment at 1 year.//

Results: Two infants had a normal or mildly abnormal EEG within 8 h of birth and neurodevelopmental outcome was normal. Seven infants had severely depressed background activity in the first 8 h of life. In 3 infants the EEG activity recovered within 12-24 h showing continuous activity with no or only minor abnormalities. All these infants had a normal outcome. The remaining 4 infants, who also had an initially inactive recording, subsequently developed severe background abnormalities. At follow-up, two infants had died and the remainder developed major neurological sequelae.//


Conclusions: Early EEG is an excellent prognostic indicator for a favourable outcome if normal within the first 8 h of life and for a poor outcome if the background activity continues to be inactive or grossly abnormal beyond 8-12 h of life. However, an inactive or very depressed EEG within the first 8 h of life can be associated with good outcome if the EEG activity recovers within 12 h.},
            issn = {1388-2457},
        keywords = {Neonatal EEG, Hypoxic ischaemic encephalopathy, Neurodevelopmental outcome}
}