%0 Journal Article
%A Taylor, Peter
%A Rajendram, Rathie
%A Hanna, Stephanie
%A Wilson, Victoria
%A Pell, Julie
%A Li, Chunhei
%A Cook, Anne
%A Gattamaneni, Rao
%A Plowman, Nicholas
%A Jackson, Sue
%A Hills, Robert
%A French, Robert
%A Uddin, Jimmy M
%A Lee, Richard WJ
%A Dayan, Colin M
%A CIRTED, Investigators
%D 2023
%F discovery:10177047
%I ENDOCRINE SOC
%J The Journal of Clinical Endocrinology & Metabolism
%K graves orbitopathy, CAS, GOQOL, azathioprine, radiotherapy, CIRTED
%N 10
%P 2615-2625
%T Factors Predicting Long-term Outcome and the Need for Surgery in Graves Orbitopathy: Extended Follow-up From the CIRTED Trial
%U https://discovery.ucl.ac.uk/id/eprint/10177047/
%V 108
%X UNLABELLED: Graves Orbitopathy is both disabling and disfiguring. Medical therapies to reduce inflammation are widely used, but there is limited trial data beyond 18 months of follow-up. METHODS: 3 year follow-up of a subset of the CIRTED trial (N=68) which randomized patients to receive high dose oral steroid with azathioprine/placebo and radiotherapy/sham radiotherapy. RESULTS: Data were available at 3 years from 68 of 126 randomised subjects (54%). No additional benefit was seen at 3 years for patients randomized to azathioprine or radiotherapy with regard to a Binary Clinical Composite Outcome Measure, modified EUGOGO score or Ophthalmopathy Index.Clinical Activity Score (CAS), Ophthalmopathy Index and Total Eye Score improved over 3 years (p<0.001). However, quality of life at 3 years remained poor. Of 64 individuals with available surgical outcome data, 24/64 (37.5%) required surgical intervention. Disease duration of greater than 6 months before treatment was associated with increased need for surgery OR=16.8 (95%CI 2.95, 95.0) p=0.001. Higher baseline levels of CAS, Ophthalmopathy Index and Total Eye Score but not early improvement in CAS were associated with increased requirement for surgery. CONCLUSION: In this long-term follow-up from a clinical trial, 3 year outcomes remained suboptimal with ongoing poor quality of life and high numbers requiring surgery. Importantly, reduction in CAS in the first year, a commonly used surrogate outcome measure, was not associated with improved long-term outcomes.
%Z © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).