TY  - INPR
Y1  - 2023/09/25/
TI  - A viewpoint on therapeutic approaches and unmet needs in the management of young people with juvenile Sj?gren?s Syndrome
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
KW  - Biologic therapies
KW  -  children and adolescents
KW  -  dryness
KW  -  Sjögren disease in children
KW  -  treatment
KW  -  unmet needs
ID  - discovery10175962
AV  - public
N2  - Sjögren disease (SjD) in children is a rare disease phenotype, categorized with onset before the age of 18. Due to differences in clinical presentation in children and young people compared with adults, the disease is under-recognised and under-diagnosed in younger patients. Consequently, no evidence-based treatment and management recommendations are available for children with SjD, despite efforts to develop paediatric expert-led consensus guidelines in recent years and incorporate management recommendations for children in adult guidelines. This article highlights the potential differences in assessment strategies for children and young people compared with adults due to differences in clinical manifestations and screening tests between SjD in children and adult-onset SjD. Furthermore, it summarises the evidence concerning the use and efficacy of various treatments in children with SjD. Higher-quality research is needed to evaluate the safety and efficacy of various off-label treatments used or recommended for use in child patients with SjD and investigate long-term disease outcomes.
JF  - touchREVIEWS in Respiratory & Pulmonary Diseases
A1  - Ciurtin, Coziana
A1  - Price, Elizabeth
UR  - https://www.touchimmunology.com/paediatric-rheumatology/journal-articles/a-viewpoint-on-therapeutic-approaches-and-unmet-needs-in-the-management-of-young-people-with-sj%D3%A7gren-disease/?rl=www.touchimmunology.com/paediatric-rheumatology/journal-articles
ER  -