TY  - JOUR
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VL  - 12
KW  - Cancer
KW  -  chronobiology
KW  -  circadian
KW  -  immunotherapy
KW  -  melanoma
A1  - Gonçalves, Lisa
A1  - Gonçalves, Duarte
A1  - Esteban-Casanelles, Teresa
A1  - Barroso, Tiago
A1  - Soares de Pinho, Inês
A1  - Lopes-Brás, Raquel
A1  - Esperança-Martins, Miguel
A1  - Patel, Vanessa
A1  - Torres, Sofia
A1  - Teixeira de Sousa, Rita
A1  - Mansinho, André
A1  - Costa, Luís
PB  - MDPI AG
JF  - Cells
AV  - public
TI  - Immunotherapy around the Clock: Impact of Infusion Timing on Stage IV Melanoma Outcomes
Y1  - 2023/08/15/
ID  - discovery10175867
UR  - https://doi.org/10.3390/cells12162068
IS  - 16
N2  - Although the impact of circadian timing on immunotherapy has yet to be integrated into clinical practice, chronoimmunotherapy is an emerging and promising field as circadian oscillations are observed in immune cell numbers as well as the expression of immunotherapy targets, e.g., programmed cell death protein-1 and its ligand programmed death ligand 1. Concurrent retrospective studies suggest that morning infusions may lead to higher effectiveness of immune checkpoint inhibitors in melanoma, non-small cell lung cancer, and kidney cancer. This paper discusses the results of a retrospective study (2016-2022) exploring the impact of infusion timing on the outcomes of all 73 patients with stage IV melanoma receiving immunotherapy at a particular medical center. While the median overall survival (OS) was 24.2 months (95% confidence interval [CI] 9.04-39.8), for a median follow-up of 15.3 months, our results show that having more than 75% of infusions in the afternoon results in shorter median OS (14.9 vs. 38.1 months; hazard ratio 0.45 [CI 0.23-0.86]; p < 0.01) with more expressive impacts on particular subgroups: women, older patients, and patients with a lower tumor burden at the outset of immunotherapy. Our findings highlight the potential benefits of follow-up validation in prospective and translational randomized studies.
ER  -