<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10175867> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/title> "Immunotherapy around the Clock: Impact of Infusion Timing on Stage IV Melanoma Outcomes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/abstract> "Although the impact of circadian timing on immunotherapy has yet to be integrated into clinical practice, chronoimmunotherapy is an emerging and promising field as circadian oscillations are observed in immune cell numbers as well as the expression of immunotherapy targets, e.g., programmed cell death protein-1 and its ligand programmed death ligand 1. Concurrent retrospective studies suggest that morning infusions may lead to higher effectiveness of immune checkpoint inhibitors in melanoma, non-small cell lung cancer, and kidney cancer. This paper discusses the results of a retrospective study (2016-2022) exploring the impact of infusion timing on the outcomes of all 73 patients with stage IV melanoma receiving immunotherapy at a particular medical center. While the median overall survival (OS) was 24.2 months (95% confidence interval [CI] 9.04-39.8), for a median follow-up of 15.3 months, our results show that having more than 75% of infusions in the afternoon results in shorter median OS (14.9 vs. 38.1 months; hazard ratio 0.45 [CI 0.23-0.86]; p < 0.01) with more expressive impacts on particular subgroups: women, older patients, and patients with a lower tumor burden at the outset of immunotherapy. Our findings highlight the potential benefits of follow-up validation in prospective and translational randomized studies."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/date> "2023-08-15" .
<https://discovery.ucl.ac.uk/id/document/1623443> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/volume> "12" .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/issue> "16" .
<https://discovery.ucl.ac.uk/id/org/ext-16a556591fc6878b9a1e5626e5d3b570> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-16a556591fc6878b9a1e5626e5d3b570> <http://xmlns.com/foaf/0.1/name> "MDPI AG"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-a3af7a2add5e0f31e3e9d14fe293947f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-a3af7a2add5e0f31e3e9d14fe293947f> <http://xmlns.com/foaf/0.1/name> "Cells"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-a3af7a2add5e0f31e3e9d14fe293947f> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> .
<https://discovery.ucl.ac.uk/id/eprint/10175867> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10175867#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10175867#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> .
<https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> <http://xmlns.com/foaf/0.1/givenName> "Inês"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> <http://xmlns.com/foaf/0.1/familyName> "Soares de Pinho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a976d95e530cc77ac44b27b42487bfe4> <http://xmlns.com/foaf/0.1/name> "Inês Soares de Pinho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> <http://xmlns.com/foaf/0.1/givenName> "André"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> <http://xmlns.com/foaf/0.1/familyName> "Mansinho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3227b39b4d016945776c8c1ccd5e2c5a> <http://xmlns.com/foaf/0.1/name> "André Mansinho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> <http://xmlns.com/foaf/0.1/givenName> "Duarte"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> <http://xmlns.com/foaf/0.1/familyName> "Gonçalves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15f96227440488ca7984ae021d101413> <http://xmlns.com/foaf/0.1/name> "Duarte Gonçalves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> <http://xmlns.com/foaf/0.1/givenName> "Vanessa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> <http://xmlns.com/foaf/0.1/familyName> "Patel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-97f3b2dd5ec9ad7ff27ef433c8b3e4c1> <http://xmlns.com/foaf/0.1/name> "Vanessa Patel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> <http://xmlns.com/foaf/0.1/givenName> "Sofia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> <http://xmlns.com/foaf/0.1/familyName> "Torres"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0b542b1d0207ab2a1b5003371ca4d5a0> <http://xmlns.com/foaf/0.1/name> "Sofia Torres"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> <http://xmlns.com/foaf/0.1/givenName> "Raquel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> <http://xmlns.com/foaf/0.1/familyName> "Lopes-Brás"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ee1644becaf877b95131398774fcd42> <http://xmlns.com/foaf/0.1/name> "Raquel Lopes-Brás"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> <http://xmlns.com/foaf/0.1/givenName> "Luís"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> <http://xmlns.com/foaf/0.1/familyName> "Costa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3471750e83b98ad847415cb1dcdb9e9> <http://xmlns.com/foaf/0.1/name> "Luís Costa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> <http://xmlns.com/foaf/0.1/givenName> "Tiago"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> <http://xmlns.com/foaf/0.1/familyName> "Barroso"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9914d524611ef92e33fe39ccc60a1efd> <http://xmlns.com/foaf/0.1/name> "Tiago Barroso"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> <http://xmlns.com/foaf/0.1/givenName> "Lisa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> <http://xmlns.com/foaf/0.1/familyName> "Gonçalves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de88a35b67354d379b9f3cd6152329a2> <http://xmlns.com/foaf/0.1/name> "Lisa Gonçalves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> <http://xmlns.com/foaf/0.1/givenName> "Rita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> <http://xmlns.com/foaf/0.1/familyName> "Teixeira de Sousa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-283ae54ffa70eebabd1c18dfdeb6428c> <http://xmlns.com/foaf/0.1/name> "Rita Teixeira de Sousa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> <http://xmlns.com/foaf/0.1/givenName> "Miguel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> <http://xmlns.com/foaf/0.1/familyName> "Esperança-Martins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cbe2fd4f3bce0124393ccd41f19ecaee> <http://xmlns.com/foaf/0.1/name> "Miguel Esperança-Martins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> <http://xmlns.com/foaf/0.1/givenName> "Teresa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> <http://xmlns.com/foaf/0.1/familyName> "Esteban-Casanelles"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edbf2be45d86317de9b8b2ce127dcf67> <http://xmlns.com/foaf/0.1/name> "Teresa Esteban-Casanelles"^^<http://www.w3.org/2001/XMLSchema#string> .
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