eprintid: 10175363
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/17/53/63
datestamp: 2023-08-17 11:43:35
lastmod: 2023-08-17 11:43:35
status_changed: 2023-08-17 11:43:35
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Davila, Mariela Martinez
creators_name: Papada, Efstathia
title: The Role of Plant-Derived Natural Products in the Management of Inflammatory Bowel Disease—What Is the Clinical Evidence So Far?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
keywords: phytochemicals; inflammatory bowel disease; gut microbiota; Mastiha; Curcumin; Boswellia serrata; Artemisia absinthium
note: © 2023 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
abstract: Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are a major healthcare challenge worldwide. Disturbances in the immune system and gut microbiota followed by environmental triggers are thought to be part of the aetiological factors. Current treatment for IBD includes corticosteroids, immunosuppressants, and other biologic agents; however, some patients are still unresponsive, and these are also linked to high financial load and severe side effects. Plant-derived natural products are rich in phytochemicals and have been used as healing agents in several diseases since antiquity due to their antioxidant, anti-inflammatory, and immunomodulatory properties, as well as gut microbiota modulation. Numerous in vitro and in vivo studies have shown that phytochemicals act in key pathways that are associated with the pathogenesis of IBD. It is also reported that the use of plant-derived natural products as complementary treatments is increasing amongst patients with IBD to avoid the side effects accompanying standard medical treatment. This review summarises the relevant evidence around the use of plant-derived natural products in the management of IBD, with specific focus on the clinical evidence so far for Curcumin, Mastiha, Boswellia serrata, and Artemisia absinthium.
date: 2023-08
date_type: published
publisher: MDPI AG
official_url: https://doi.org/10.3390/life13081703
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2044665
doi: 10.3390/life13081703
lyricists_name: Papada, Efstathia
lyricists_id: PAPAD40
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Life
volume: 13
number: 8
article_number: 1703
citation:        Davila, Mariela Martinez;    Papada, Efstathia;      (2023)    The Role of Plant-Derived Natural Products in the Management of Inflammatory Bowel Disease—What Is the Clinical Evidence So Far?                   Life , 13  (8)    , Article 1703.  10.3390/life13081703 <https://doi.org/10.3390/life13081703>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10175363/1/life-13-01703.pdf