@article{discovery10174993, note = {Copyright: {\copyright} 2023 Burgess S et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.}, publisher = {F1000 Research Ltd}, month = {January}, volume = {4}, year = {2020}, title = {Guidelines for performing Mendelian randomization investigations [version 2; peer review: 2 approved]}, journal = {Wellcome Open Research}, keywords = {Mendelian randomization, causal inference, genetic epidemiology, guidelines}, issn = {2398-502X}, url = {https://doi.org/10.12688/wellcomeopenres.15555.2}, author = {Burgess, S and Davey Smith, G and Davies, NM and Dudbridge, F and Gill, D and Glymour, MM and Hartwig, FP and Holmes, MV and Minelli, C and Relton, CL and Theodoratou, E}, abstract = {This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.} }