TY  - INPR
N1  - © 2023 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the
terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
UR  - https://doi.org/10.1161/HYPERTENSIONAHA.121.17109
Y1  - 2023/08/07/
A1  - Taylor, Hannah CM
A1  - Chaturvedi, Nishi
A1  - Davey Smith, George
A1  - Ferreira, Diana LS
A1  - Fraser, Abigail
A1  - Howe, Laura D
A1  - Hughes, Alun D
A1  - Lawlor, Debbie A
A1  - Timpson, Nic J
A1  - Park, Chloe M
AV  - public
KW  - adolescents
KW  -  biomarker
KW  -  body surface area
KW  -  morbidity
KW  -  overweight
ID  - discovery10174926
N2  - BACKGROUND: Left ventricular mass (LVM) is an important predictor of cardiovascular risk. In adolescence, LVM is commonly indexed to height2.7, although some evidence suggests that this may not fully account for sex differences. METHODS: We investigated appropriate allometric scaling of LVM to height, total lean mass, and body surface area, in a UK birth cohort of 2039 healthy adolescents (17±1 years). Allometric relationships were determined by linear regression stratified by sex, following log transformation of x and y variables [log(y)=a+b×log(x)], b is the allometric exponent. RESULTS: Log (LVM) showed linear relationships with log(height) and log(lean mass). Biased estimates of slope resulted when the sexes were pooled. The exponents were lower than the conventional estimate of 2.7 for males (mean [95% CI]=1.66 [1.30-2.03]) and females (1.58 [1.27-1.90]). When LVM was indexed to lean mass, the exponent was 1.16 (1.05-1.26) for males and 1.07 (0.97-1.16) for females. When LVM was indexed to estimated body surface area, the exponent was 1.53 (1.40-1.66) for males and 1.34 (1.24-1.45) for females. CONCLUSIONS: Allometric exponents derived from pooled data, including men and women without adjustment for sex were biased, possibly due to sex differences in body composition. We suggest that when assessing LVM, clinicians should consider body size, body composition, sex, and age. Our observations may also have implications for the identification of young individuals with cardiac hypertrophy.
SN  - 0194-911X
PB  - Ovid Technologies (Wolters Kluwer Health)
JF  - Hypertension
TI  - Is Height2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences
ER  -