<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10174132> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/title> "Construct validity and reliability of the Assessment of Systemic Sclerosis-Associated Raynaud’s Phenomenon (ASRAP) questionnaire"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/abstract> "Objectives:\r\nAssessment of construct validity and reliability of a novel patient-reported outcome (PRO) instrument for assessing the severity and impact of RP in SSc. /\r\n\r\nMethods:\r\nAn international multicentre study validation study of the 27-item Assessment of Systemic Sclerosis-Associated Raynaud’s Phenomenon (ASRAP) and 10-item short-form (ASRAP-SF) questionnaires. The relationship between ASRAP questionnaires and demographics, clinical phenotype and legacy instruments for assessing SSc-RP severity, disability and pain was assessed. Repeatability was evaluated at 1 week. Anchor-based statements of health status facilitated assessment of ASRAP thresholds of meaning. /\r\n\r\nResults:\r\nA total of 420 SSc subjects were enrolled. There was good correlation between ASRAP (and ASRAP-SF) with RP visual analogue scale (VAS) and Scleroderma Health Assessment Questionnaire RP VAS (rho range 0.648–0.727, P < 0.001). Correlation with diary-based assessment of SSc-RP attack frequency and duration was lower (rho range 0.258–0.504, P < 0.001). ASRAP questionnaires had good correlation with instruments for assessing disability, hand function, pain and global health assessment (rho range 0.427–0.575, P < 0.001). Significantly higher ASRAP scores were identified in smokers, patients with active digital ulceration (DU), previous history of DU and calcinosis (P < 0.05 for all comparisons). There was excellent repeatability at 1 week among patients with stable SSc-RP symptoms (intra-class coefficients of 0.891 and 0.848, P < 0.001). Patient-acceptable symptom state thresholds for ASRAP and ASRAP-SF were 45.34 and 45.77, respectively. A preliminary Minimally Important Clinical Difference threshold of 4.17 (95% CI 0.53, 7.81, P = 0.029) was estimated. /\r\n\r\nConclusion:\r\nASRAP and ASRAP-SF questionnaires are valid and reliable novel PRO instruments for assessing the severity and impact of SSc-RP."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/date> "2024-05" . <https://discovery.ucl.ac.uk/id/document/1621182> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/volume> "63" . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/issue> "5" . <https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> <http://xmlns.com/foaf/0.1/name> "Oxford University Press (OUP)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> . <https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> <http://xmlns.com/foaf/0.1/name> "Rheumatology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-384ffa338339905fbb799c57187e0558> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-384ffa338339905fbb799c57187e0558> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7a0613523e5cbcced95283508432080a> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-7a0613523e5cbcced95283508432080a> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> . <https://discovery.ucl.ac.uk/id/eprint/10174132> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> . <https://discovery.ucl.ac.uk/id/eprint/10174132#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> . <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> <http://xmlns.com/foaf/0.1/givenName> "Robyn T"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> <http://xmlns.com/foaf/0.1/familyName> "Domsic"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e453319f9c0fbb1e37337fef781f1202> <http://xmlns.com/foaf/0.1/name> "Robyn T Domsic"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> <http://xmlns.com/foaf/0.1/givenName> "Christopher P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> <http://xmlns.com/foaf/0.1/familyName> "Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22554ab5ecede16dd9688fd8d11e398a> <http://xmlns.com/foaf/0.1/name> "Christopher P Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> <http://xmlns.com/foaf/0.1/givenName> "Ami A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> <http://xmlns.com/foaf/0.1/familyName> "Shah"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bd086bf2ebfc2d6e1f76fc14d99abbd9> <http://xmlns.com/foaf/0.1/name> "Ami A Shah"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> <http://xmlns.com/foaf/0.1/givenName> "Laura K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> <http://xmlns.com/foaf/0.1/familyName> "Hummers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f810f9967f53b9f61f95f118de4191ec> <http://xmlns.com/foaf/0.1/name> "Laura K Hummers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> <http://xmlns.com/foaf/0.1/givenName> "Lan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> <http://xmlns.com/foaf/0.1/familyName> "Yu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-54549fb8fc4b95bce7ca16e03d4839df> <http://xmlns.com/foaf/0.1/name> "Lan Yu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> <http://xmlns.com/foaf/0.1/givenName> "Lesley Ann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> <http://xmlns.com/foaf/0.1/familyName> "Saketkoo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-df110566ad051f70309782d91bfd761e> <http://xmlns.com/foaf/0.1/name> "Lesley Ann Saketkoo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> <http://xmlns.com/foaf/0.1/givenName> "Ariane L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> <http://xmlns.com/foaf/0.1/familyName> "Herrick"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2e9e8e8360e972b358153e453a2c76ac> <http://xmlns.com/foaf/0.1/name> "Ariane L Herrick"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> <http://xmlns.com/foaf/0.1/givenName> "John D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> <http://xmlns.com/foaf/0.1/familyName> "Pauling"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cfc7141a6ce09cc1ade5a0e6b1da9978> <http://xmlns.com/foaf/0.1/name> "John D Pauling"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> <http://xmlns.com/foaf/0.1/givenName> "Tracy M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> <http://xmlns.com/foaf/0.1/familyName> "Frech"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d9760f8b9b073e9bdaae9f5c183d4339> <http://xmlns.com/foaf/0.1/name> "Tracy M Frech"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7a0613523e5cbcced95283508432080a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7a0613523e5cbcced95283508432080a> 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