eprintid: 10174090 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/17/40/90 datestamp: 2023-07-26 14:39:15 lastmod: 2023-07-26 14:39:15 status_changed: 2023-07-26 14:39:15 type: article metadata_visibility: show sword_depositor: 699 creators_name: Ibitoye, Richard T creators_name: Castro, Patricia creators_name: Cooke, Josie creators_name: Allum, John creators_name: Arshad, Qadeer creators_name: Murdin, Louisa creators_name: Wardlaw, Joanna creators_name: Kaski, Diego creators_name: Sharp, David J creators_name: Bronstein, Adolfo M title: A link between frontal white matter integrity and dizziness in cerebral small vessel disease ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 keywords: Dizziness, Small vessel disease, Older, Balance, White matter note: Copyright © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance. date: 2022 date_type: published publisher: ELSEVIER SCI LTD official_url: https://doi.org/10.1016/j.nicl.2022.103098 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1964769 doi: 10.1016/j.nicl.2022.103098 medium: Print-Electronic pii: S2213-1582(22)00163-2 lyricists_name: Kaski, Diego lyricists_name: Ibitoye, Richard lyricists_id: DKASK15 lyricists_id: RIBIT65 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner funding_acknowledgements: R481/0516 [Dunhill Medical Trust]; [UK Dementia Research Institute Care Research & Technology Centre]; [Centre for Injury studies at Imperial College London]; [UK De-mentia Research Institute]; [DRI Ltd - UK Medical Research Council]; [Alzheimers Society]; [Alzheimers Research UK]; [National Institute for Health Research University College London Hospitals Biomedical Research Centre] full_text_status: public publication: NeuroImage: Clinical volume: 35 article_number: 103098 pages: 12 event_location: Netherlands issn: 2213-1582 citation: Ibitoye, Richard T; Castro, Patricia; Cooke, Josie; Allum, John; Arshad, Qadeer; Murdin, Louisa; Wardlaw, Joanna; ... Bronstein, Adolfo M; + view all <#> Ibitoye, Richard T; Castro, Patricia; Cooke, Josie; Allum, John; Arshad, Qadeer; Murdin, Louisa; Wardlaw, Joanna; Kaski, Diego; Sharp, David J; Bronstein, Adolfo M; - view fewer <#> (2022) A link between frontal white matter integrity and dizziness in cerebral small vessel disease. NeuroImage: Clinical , 35 , Article 103098. 10.1016/j.nicl.2022.103098 <https://doi.org/10.1016/j.nicl.2022.103098>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10174090/1/1-s2.0-S2213158222001632-main.pdf