TY  - JOUR
UR  - https://doi.org/10.1016/j.nicl.2022.103098
KW  - Dizziness
KW  -  Small vessel disease
KW  -  Older
KW  -  Balance
KW  -  White matter
TI  - A link between frontal white matter integrity and dizziness in cerebral small vessel disease
N2  - One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance.
A1  - Ibitoye, Richard T
A1  - Castro, Patricia
A1  - Cooke, Josie
A1  - Allum, John
A1  - Arshad, Qadeer
A1  - Murdin, Louisa
A1  - Wardlaw, Joanna
A1  - Kaski, Diego
A1  - Sharp, David J
A1  - Bronstein, Adolfo M
PB  - ELSEVIER SCI LTD
VL  - 35
Y1  - 2022///
SN  - 2213-1582
N1  - Copyright © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
ID  - discovery10174090
AV  - public
EP  - 12
JF  - NeuroImage: Clinical
ER  -