eprintid: 10173980
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/17/39/80
datestamp: 2023-07-26 14:31:23
lastmod: 2023-07-26 14:31:23
status_changed: 2023-07-26 14:31:23
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Ibitoye, Richard T
creators_name: Mallas, Emma-Jane
creators_name: Bourke, Niall J
creators_name: Kaski, Diego
creators_name: Bronstein, Adolfo M
creators_name: Sharp, David J
title: The human vestibular cortex: functional anatomy of OP2, its connectivity and the effect of vestibular disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, perception, visual, vestibular neuritis, vestibular cortex, INDEPENDENT COMPONENT ANALYSIS, NEURONAL-ACTIVITY, DEFAULT MODE, MOTION, BRAIN, FMRI, RESPONSES, ROBUST, COMPENSATION, PERCEPTION
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abstract: Area OP2 in the posterior peri-sylvian cortex has been proposed to be the core human vestibular cortex. We investigated the functional anatomy of OP2 and adjacent areas (OP2+) using spatially constrained independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. Ten ICA-derived subregions were identified. OP2+ responses to vestibular and visual motion were analyzed in 17 controls and 17 right-sided vestibular neuritis patients who had previously undergone caloric and optokinetic stimulation during fMRI. In controls, a posterior part of right OP2+ showed: (i) direction-selective responses to visual motion and (ii) activation during caloric stimulation that correlated positively with perceived self-motion, and negatively with visual dependence and peak slow-phase nystagmus velocity. Patients showed abnormal OP2+ activity, with an absence of visual or caloric activation of the healthy ear and no correlations with vertigo or visual dependence-despite normal slow-phase nystagmus responses to caloric stimulation. Activity in a lateral part of right OP2+ correlated with chronic visually induced dizziness in patients. In summary, distinct functional subregions of right OP2+ show strong connectivity to other vestibular areas and a profile of caloric and visual responses, suggesting a central role for vestibular function in health and disease.
date: 2022-03-02
date_type: published
publisher: OXFORD UNIV PRESS INC
official_url: https://doi.org/10.1093/cercor/bhac085
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1942993
doi: 10.1093/cercor/bhac085
medium: Print
pii: 6540624
lyricists_name: Kaski, Diego
lyricists_name: Ibitoye, Richard
lyricists_id: DKASK15
lyricists_id: RIBIT65
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: MR/J004685/1 [UK Medical Research Council]; R481/0516 [Dunhill Medical Trust]; [Imperial National Institute for Health Research (NIHR) Biomedical Research Centre]; [NIHR University College London Hospitals Biomedical Research Centre]; [UK Dementia Research Institute Care Research & Technology Centre]; [Centre for Injury studies at Imperial College London]
full_text_status: public
publication: Cerebral Cortex
volume: 33
number: 3
pagerange: 567-582
pages: 16
event_location: United States
citation:        Ibitoye, Richard T;    Mallas, Emma-Jane;    Bourke, Niall J;    Kaski, Diego;    Bronstein, Adolfo M;    Sharp, David J;      (2022)    The human vestibular cortex: functional anatomy of OP2, its connectivity and the effect of vestibular disease.                   Cerebral Cortex , 33  (3)   pp. 567-582.    10.1093/cercor/bhac085 <https://doi.org/10.1093/cercor%2Fbhac085>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10173980/1/bhac085.pdf