TY  - JOUR
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
ID  - discovery10173980
AV  - public
JF  - Cerebral Cortex
EP  - 582
N2  - Area OP2 in the posterior peri-sylvian cortex has been proposed to be the core human vestibular cortex. We investigated the functional anatomy of OP2 and adjacent areas (OP2+) using spatially constrained independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. Ten ICA-derived subregions were identified. OP2+ responses to vestibular and visual motion were analyzed in 17 controls and 17 right-sided vestibular neuritis patients who had previously undergone caloric and optokinetic stimulation during fMRI. In controls, a posterior part of right OP2+ showed: (i) direction-selective responses to visual motion and (ii) activation during caloric stimulation that correlated positively with perceived self-motion, and negatively with visual dependence and peak slow-phase nystagmus velocity. Patients showed abnormal OP2+ activity, with an absence of visual or caloric activation of the healthy ear and no correlations with vertigo or visual dependence-despite normal slow-phase nystagmus responses to caloric stimulation. Activity in a lateral part of right OP2+ correlated with chronic visually induced dizziness in patients. In summary, distinct functional subregions of right OP2+ show strong connectivity to other vestibular areas and a profile of caloric and visual responses, suggesting a central role for vestibular function in health and disease.
VL  - 33
UR  - https://doi.org/10.1093/cercor/bhac085
SP  - 567
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  perception
KW  -  visual
KW  -  vestibular neuritis
KW  -  vestibular cortex
KW  -  INDEPENDENT COMPONENT ANALYSIS
KW  -  NEURONAL-ACTIVITY
KW  -  DEFAULT MODE
KW  -  MOTION
KW  -  BRAIN
KW  -  FMRI
KW  -  RESPONSES
KW  -  ROBUST
KW  -  COMPENSATION
KW  -  PERCEPTION
TI  - The human vestibular cortex: functional anatomy of OP2, its connectivity and the effect of vestibular disease
IS  - 3
Y1  - 2022/03/02/
PB  - OXFORD UNIV PRESS INC
A1  - Ibitoye, Richard T
A1  - Mallas, Emma-Jane
A1  - Bourke, Niall J
A1  - Kaski, Diego
A1  - Bronstein, Adolfo M
A1  - Sharp, David J
ER  -