eprintid: 10173222
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/17/32/22
datestamp: 2023-07-13 13:32:14
lastmod: 2024-10-30 17:52:46
status_changed: 2023-07-13 13:32:14
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Lazarus, Jeffrey V
creators_name: Mark, Henry E
creators_name: Allen, Alina M
creators_name: Arab, Juan Pablo
creators_name: Carrieri, Patrizia
creators_name: Noureddin, Mazen
creators_name: Alazawi, William
creators_name: Alkhouri, Naim
creators_name: Alqahtani, Saleh A
creators_name: Arrese, Marco
creators_name: Bataller, Ramon
creators_name: Berg, Thomas
creators_name: Brennan, Paul N
creators_name: Burra, Patrizia
creators_name: Castro-Narro, Graciela E
creators_name: Cortez-Pinto, Helena
creators_name: Cusi, Kenneth
creators_name: Dedes, Nikos
creators_name: Duseja, Ajay
creators_name: Francque, Sven M
creators_name: Hagström, Hannes
creators_name: Huang, Terry T-K
creators_name: Wajcman, Dana Ivancovsky
creators_name: Kautz, Achim
creators_name: Kopka, Christopher J
creators_name: Krag, Aleksander
creators_name: Miller, Veronica
creators_name: Newsome, Philip N
creators_name: Rinella, Mary E
creators_name: Romero, Diana
creators_name: Sarin, Shiv Kumar
creators_name: Silva, Marcelo
creators_name: Spearman, C Wendy
creators_name: Tsochatzis, Emmanuel A
creators_name: Valenti, Luca
creators_name: Villota-Rivas, Marcela
creators_name: Zelber-Sagi, Shira
creators_name: Schattenberg, Jörn M
creators_name: Wong, Vincent Wai-Sun
creators_name: Younossi, Zobair M
creators_name: Healthy Livers, Healthy Lives, Collaborators
title: A global research priority agenda to advance public health responses to fatty liver disease
ispublished: inpress
subjects: RFH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G91
keywords: Delphi method, Global health, NAFLD/NASH, Non-communicable disease (NCD), Steatotic liver disease
note: © 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: BACKGROUND & AIMS: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. METHODS: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. RESULTS: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of 'agree' responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement ('agree' + 'somewhat agree'); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% 'agree'), 13 priorities had <80% 'agree', with greater reliance on 'somewhat agree' to achieve >90% combined agreement. CONCLUSIONS: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. IMPACT AND IMPLICATIONS: An estimated 38% of adults and 13% of children and adolescents worldwide have fatty liver disease, making it the most prevalent liver disease in history. Despite substantial scientific progress in the past three decades, the burden continues to grow, with an urgent need to advance understanding of how to prevent, manage, and treat the disease. Through a global consensus process, a multidisciplinary group agreed on 28 research priorities covering a broad range of themes, from disease burden, treatment, and health system responses to awareness and policy. The findings have relevance for clinical and non-clinical researchers as well as funders working on fatty liver disease and non-communicable diseases more broadly, setting out a prioritised, ranked research agenda for turning the tide on this fast-growing public health threat.
date: 2023-06-20
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.jhep.2023.04.035
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2031514
doi: 10.1016/j.jhep.2023.04.035
medium: Print-Electronic
pii: S0168-8278(23)00323-9
lyricists_name: Tsochatzis, Emmanouil
lyricists_id: ETSOC40
actors_name: Tsochatzis, Emmanouil
actors_id: ETSOC40
actors_role: owner
full_text_status: public
publication: Journal of Hepatology
event_location: Netherlands
citation:        Lazarus, Jeffrey V;    Mark, Henry E;    Allen, Alina M;    Arab, Juan Pablo;    Carrieri, Patrizia;    Noureddin, Mazen;    Alazawi, William;                                                                                                                                         ... Healthy Livers, Healthy Lives, Collaborators; + view all <#>        Lazarus, Jeffrey V;  Mark, Henry E;  Allen, Alina M;  Arab, Juan Pablo;  Carrieri, Patrizia;  Noureddin, Mazen;  Alazawi, William;  Alkhouri, Naim;  Alqahtani, Saleh A;  Arrese, Marco;  Bataller, Ramon;  Berg, Thomas;  Brennan, Paul N;  Burra, Patrizia;  Castro-Narro, Graciela E;  Cortez-Pinto, Helena;  Cusi, Kenneth;  Dedes, Nikos;  Duseja, Ajay;  Francque, Sven M;  Hagström, Hannes;  Huang, Terry T-K;  Wajcman, Dana Ivancovsky;  Kautz, Achim;  Kopka, Christopher J;  Krag, Aleksander;  Miller, Veronica;  Newsome, Philip N;  Rinella, Mary E;  Romero, Diana;  Sarin, Shiv Kumar;  Silva, Marcelo;  Spearman, C Wendy;  Tsochatzis, Emmanuel A;  Valenti, Luca;  Villota-Rivas, Marcela;  Zelber-Sagi, Shira;  Schattenberg, Jörn M;  Wong, Vincent Wai-Sun;  Younossi, Zobair M;  Healthy Livers, Healthy Lives, Collaborators;   - view fewer <#>    (2023)    A global research priority agenda to advance public health responses to fatty liver disease.                   Journal of Hepatology        10.1016/j.jhep.2023.04.035 <https://doi.org/10.1016/j.jhep.2023.04.035>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10173222/1/Lazarus%20JV%20J%20Hepatol%202023.pdf