eprintid: 10173222 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/17/32/22 datestamp: 2023-07-13 13:32:14 lastmod: 2024-10-30 17:52:46 status_changed: 2023-07-13 13:32:14 type: article metadata_visibility: show sword_depositor: 699 creators_name: Lazarus, Jeffrey V creators_name: Mark, Henry E creators_name: Allen, Alina M creators_name: Arab, Juan Pablo creators_name: Carrieri, Patrizia creators_name: Noureddin, Mazen creators_name: Alazawi, William creators_name: Alkhouri, Naim creators_name: Alqahtani, Saleh A creators_name: Arrese, Marco creators_name: Bataller, Ramon creators_name: Berg, Thomas creators_name: Brennan, Paul N creators_name: Burra, Patrizia creators_name: Castro-Narro, Graciela E creators_name: Cortez-Pinto, Helena creators_name: Cusi, Kenneth creators_name: Dedes, Nikos creators_name: Duseja, Ajay creators_name: Francque, Sven M creators_name: Hagström, Hannes creators_name: Huang, Terry T-K creators_name: Wajcman, Dana Ivancovsky creators_name: Kautz, Achim creators_name: Kopka, Christopher J creators_name: Krag, Aleksander creators_name: Miller, Veronica creators_name: Newsome, Philip N creators_name: Rinella, Mary E creators_name: Romero, Diana creators_name: Sarin, Shiv Kumar creators_name: Silva, Marcelo creators_name: Spearman, C Wendy creators_name: Tsochatzis, Emmanuel A creators_name: Valenti, Luca creators_name: Villota-Rivas, Marcela creators_name: Zelber-Sagi, Shira creators_name: Schattenberg, Jörn M creators_name: Wong, Vincent Wai-Sun creators_name: Younossi, Zobair M creators_name: Healthy Livers, Healthy Lives, Collaborators title: A global research priority agenda to advance public health responses to fatty liver disease ispublished: inpress subjects: RFH divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G91 keywords: Delphi method, Global health, NAFLD/NASH, Non-communicable disease (NCD), Steatotic liver disease note: © 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/4.0/). abstract: BACKGROUND & AIMS: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. METHODS: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. RESULTS: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of 'agree' responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement ('agree' + 'somewhat agree'); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% 'agree'), 13 priorities had <80% 'agree', with greater reliance on 'somewhat agree' to achieve >90% combined agreement. CONCLUSIONS: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. IMPACT AND IMPLICATIONS: An estimated 38% of adults and 13% of children and adolescents worldwide have fatty liver disease, making it the most prevalent liver disease in history. Despite substantial scientific progress in the past three decades, the burden continues to grow, with an urgent need to advance understanding of how to prevent, manage, and treat the disease. Through a global consensus process, a multidisciplinary group agreed on 28 research priorities covering a broad range of themes, from disease burden, treatment, and health system responses to awareness and policy. The findings have relevance for clinical and non-clinical researchers as well as funders working on fatty liver disease and non-communicable diseases more broadly, setting out a prioritised, ranked research agenda for turning the tide on this fast-growing public health threat. date: 2023-06-20 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.jhep.2023.04.035 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2031514 doi: 10.1016/j.jhep.2023.04.035 medium: Print-Electronic pii: S0168-8278(23)00323-9 lyricists_name: Tsochatzis, Emmanouil lyricists_id: ETSOC40 actors_name: Tsochatzis, Emmanouil actors_id: ETSOC40 actors_role: owner full_text_status: public publication: Journal of Hepatology event_location: Netherlands citation: Lazarus, Jeffrey V; Mark, Henry E; Allen, Alina M; Arab, Juan Pablo; Carrieri, Patrizia; Noureddin, Mazen; Alazawi, William; ... Healthy Livers, Healthy Lives, Collaborators; + view all <#> Lazarus, Jeffrey V; Mark, Henry E; Allen, Alina M; Arab, Juan Pablo; Carrieri, Patrizia; Noureddin, Mazen; Alazawi, William; Alkhouri, Naim; Alqahtani, Saleh A; Arrese, Marco; Bataller, Ramon; Berg, Thomas; Brennan, Paul N; Burra, Patrizia; Castro-Narro, Graciela E; Cortez-Pinto, Helena; Cusi, Kenneth; Dedes, Nikos; Duseja, Ajay; Francque, Sven M; Hagström, Hannes; Huang, Terry T-K; Wajcman, Dana Ivancovsky; Kautz, Achim; Kopka, Christopher J; Krag, Aleksander; Miller, Veronica; Newsome, Philip N; Rinella, Mary E; Romero, Diana; Sarin, Shiv Kumar; Silva, Marcelo; Spearman, C Wendy; Tsochatzis, Emmanuel A; Valenti, Luca; Villota-Rivas, Marcela; Zelber-Sagi, Shira; Schattenberg, Jörn M; Wong, Vincent Wai-Sun; Younossi, Zobair M; Healthy Livers, Healthy Lives, Collaborators; - view fewer <#> (2023) A global research priority agenda to advance public health responses to fatty liver disease. Journal of Hepatology 10.1016/j.jhep.2023.04.035 <https://doi.org/10.1016/j.jhep.2023.04.035>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10173222/1/Lazarus%20JV%20J%20Hepatol%202023.pdf