eprintid: 10173026 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/17/30/26 datestamp: 2023-07-06 14:00:48 lastmod: 2023-07-06 14:00:48 status_changed: 2023-07-06 14:00:48 type: article metadata_visibility: show sword_depositor: 699 creators_name: Groning, F creators_name: Jones, MEH creators_name: Curtis, N creators_name: Herrel, A creators_name: O'Higgins, P creators_name: Evans, SE creators_name: Fagan, MJ title: The importance of accurate muscle modelling for biomechanical analyses: a case study with a lizard skull ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: F96 keywords: bite force, multibody dynamics analysis, skull, feeding, validation, Tupinambis note: © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. abstract: Computer-based simulation techniques such as multi-body dynamics analysis are becoming increasingly popular in the field of skull mechanics. Multi-body models can be used for studying the relationships between skull architecture, muscle morphology and feeding performance. However, to be confident in the modelling results, models need to be validated against experimental data, and the effects of uncertainties or inaccuracies in the chosen model attributes need to be assessed with sensitivity analyses. Here, we compare the bite forces predicted by a multi-body model of a lizard (Tupinambis merianae) with in vivo measurements, using anatomical data collected from the same specimen. This subject-specific model predicts bite forces that are very close to the in vivo measurements and also shows a consistent increase in bite force as the bite position is moved posteriorly on the jaw. However, the model is very sensitive to changes in muscle attributes such as fibre length, intrinsic muscle strength and force orientation, with bite force predictions varying considerably when these three variables are altered. We conclude that accurate muscle measurements are crucial to building realistic multi-body models and that subject-specific data should be used whenever possible. date: 2013-07-06 date_type: published publisher: Royal Society official_url: https://doi.org/10.1098/rsif.2013.0216 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 869706 doi: 10.1098/rsif.2013.0216 medium: Electronic-Print pii: rsif.2013.0216 lyricists_name: Evans, Susan lyricists_name: Jones, Marc lyricists_id: SEEVA33 lyricists_id: MEHJO63 actors_name: Evans, Susan actors_name: Mustafa, Adelat actors_id: SEEVA33 actors_id: AMUST21 actors_role: owner actors_role: impersonator funding_acknowledgements: BB/E007465 [BBSRC]; BB/E009204 [BBSRC]; BB/E007813 [BBSRC]; BB/H011668/1 [Biotechnology and Biological Sciences Research Council]; BB/H011390/1 [Biotechnology and Biological Sciences Research Council]; BB/H011854/1 [Biotechnology and Biological Sciences Research Council]; BB/H011854/1 [BBSRC]; BB/H011668/1 [BBSRC]; BB/H011390/1 [BBSRC] full_text_status: public publication: Journal of The Royal Society Interface volume: 10 number: 84 article_number: 20130216 place_of_pub: London UK event_location: England issn: 1742-5662 citation: Groning, F; Jones, MEH; Curtis, N; Herrel, A; O'Higgins, P; Evans, SE; Fagan, MJ; (2013) The importance of accurate muscle modelling for biomechanical analyses: a case study with a lizard skull. Journal of The Royal Society Interface , 10 (84) , Article 20130216. 10.1098/rsif.2013.0216 <https://doi.org/10.1098/rsif.2013.0216>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10173026/1/Evans_2013_The%20Importance%20of%20Accurate%20Muscle%20modelling%20Interface.pdf