@article{discovery10172239, title = {Machine learning methods for predicting protein structure from single sequences}, year = {2023}, volume = {81}, month = {August}, journal = {Current Opinion in Structural Biology}, note = {{\copyright} 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).}, url = {https://doi.org/10.1016/j.sbi.2023.102627}, abstract = {Recent breakthroughs in protein structure prediction have increasingly relied on the use of deep neural networks. These recent methods are notable in that they produce 3-D atomic coordinates as a direct output of the networks, a feature which presents many advantages. Although most techniques of this type make use of multiple sequence alignments as their primary input, a new wave of methods have attempted to use just single sequences as the input. We discuss the make-up and operating principles of these models, and highlight new developments in these areas, as well as areas for future development.}, author = {Kandathil, Shaun M and Lau, Andy M and Jones, David T}, issn = {0959-440X} }