eprintid: 10171317
rev_number: 10
eprint_status: archive
userid: 699
dir: disk0/10/17/13/17
datestamp: 2023-06-07 09:58:02
lastmod: 2024-03-25 07:10:07
status_changed: 2023-06-07 09:58:02
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Pinney, JH
creators_name: Rana, R
creators_name: Lachmann, HJ
title: Paraprotein-related renal disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: Amyloid; cast; chronic lymphocytic lymphoma; fibril;
glomerulonephritis; monoclonal gammopathy of renal significance;
myeloma; paraprotein; plasma cell; serum free light chain
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Paraprotein-related renal disease encompasses a group of rare diseases characterized by distinct renal injury caused by the direct or indirect effects of a nephrotoxic paraprotein. Individuals can present with proteinuric renal impairment or, more rarely, tubular dysfunction. Diagnosis is often challenging because of the wide range of disease manifestations, difficulties with detection of the pathogenic clone and the common finding of an incidental paraprotein in elderly individuals. The combination of a renal biopsy along with a full haematological work-up is required to link a paraprotein to kidney disease. Chemotherapy directed at the plasma cell clone can halt the production of the paraprotein, which can in turn benefit renal function. Early diagnosis and the use of rapidly effective chemotherapy agents have improved patient and renal outcomes for these disorders.
date: 2023-04
date_type: published
publisher: Elsevier
official_url: https://doi.org/10.1016/j.mpmed.2023.01.009
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2013098
doi: 10.1016/j.mpmed.2023.01.009
lyricists_name: Lachmann, Helen
lyricists_id: HJLAC80
actors_name: Lachmann, Helen
actors_name: Berkeley, Jean
actors_id: HJLAC80
actors_id: JBERK64
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Medicine
volume: 51
number: 4
pagerange: 273-279
issn: 0025-7974
citation:        Pinney, JH;    Rana, R;    Lachmann, HJ;      (2023)    Paraprotein-related renal disease.                   Medicine , 51  (4)   pp. 273-279.    10.1016/j.mpmed.2023.01.009 <https://doi.org/10.1016/j.mpmed.2023.01.009>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10171317/3/Lachmann_Paraprotein%20Related%20Renal%20Disease.pdf