TY  - JOUR
SN  - 0025-7974
UR  - https://doi.org/10.1016/j.mpmed.2023.01.009
JF  - Medicine
A1  - Pinney, JH
A1  - Rana, R
A1  - Lachmann, HJ
VL  - 51
SP  - 273
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 4
ID  - discovery10171317
N2  - Paraprotein-related renal disease encompasses a group of rare diseases characterized by distinct renal injury caused by the direct or indirect effects of a nephrotoxic paraprotein. Individuals can present with proteinuric renal impairment or, more rarely, tubular dysfunction. Diagnosis is often challenging because of the wide range of disease manifestations, difficulties with detection of the pathogenic clone and the common finding of an incidental paraprotein in elderly individuals. The combination of a renal biopsy along with a full haematological work-up is required to link a paraprotein to kidney disease. Chemotherapy directed at the plasma cell clone can halt the production of the paraprotein, which can in turn benefit renal function. Early diagnosis and the use of rapidly effective chemotherapy agents have improved patient and renal outcomes for these disorders.
PB  - Elsevier
KW  - Amyloid; cast; chronic lymphocytic lymphoma; fibril;
glomerulonephritis; monoclonal gammopathy of renal significance;
myeloma; paraprotein; plasma cell; serum free light chain
TI  - Paraprotein-related renal disease
EP  - 279
AV  - public
Y1  - 2023/04//
ER  -